Recombinant Human ELAC2, GST-tagged

• Cat.No.: ELAC2-12395H
• Product Overview: Recombinant Human ELAC2 protein, fused to GST-tag, was expressed in E.coli and purified by GSH-sepharose.

Specification

• Description: The protein encoded by this gene has a C-terminal domain with tRNA 3′ processing endoribonuclease activity, which catalyzes the removal of the 3 trailer from precursor tRNAs. The protein also interacts with activated Smad family member 2 (Smad2) and its nuclear partner forkhead box H1 (also known as FAST-1), and reduced expression can suppress transforming growth factor-beta induced growth arrest. Mutations in this gene result in an increased risk of prostate cancer. Multiple transcript variants encoding different isoforms have been found for this gene.
• Source: E.coli
• Species: Human
• Tag: GST
• Protein length: 86-385a.a.
• Storage: The protein is stored in PBS buffer at -20℃. Avoid repeated freezing and thawing cycles.
• Storage Buffer: 1M PBS (58mM Na2HPO4,17mM NaH2PO4, 68mM NaCl, pH8. ) added with 100mM GSH and 1% Triton X-100,15%glycerol.

Gene Information

• Gene Name: ELAC2 elaC homolog 2 (E. coli) [ Homo sapiens ]
• Official Symbol: ELAC2
• Synonyms: ELAC2; elaC homolog 2 (E. coli); elaC (E. coli) homolog 2; zinc phosphodiesterase ELAC protein 2; FLJ10530; HPC2; tRNase Z (long form); RNase Z 2; tRNase Z 2; ribonuclease Z 2; tRNA 3 endonuclease 2; elaC homolog protein 2; heredity prostate cancer protein 2; putative prostate cancer susceptibility protein HPC2/ELAC2; ELC2; FLJ36693; FLJ42848
• Gene ID: 60528
• mRNA Refseq: NM_001165962
• Protein Refseq: NP_001159434
• MIM: 605367
• UniProt ID: Q9BQ52
• Chromosome Location: 17p11.2
• Pathway: RNA transport, organism-specific biosystem; RNA transport, conserved biosystem
• Function: endonuclease activity; hydrolase activity; metal ion binding