Recombinant Human ELAC2 Protein, Myc/DDK-tagged, C13 and N15-labeled

• Cat.No.: ELAC2-6299H
• Product Overview: ELAC2 MS Standard C13 and N15-labeled recombinant protein (NP_060597) with a C-terminal MYC/DDK tag, was expressed in HEK293 cells.

Specification

• Description: The protein encoded by this gene has a C-terminal domain with tRNA 3′ processing endoribonuclease activity, which catalyzes the removal of the 3' trailer from precursor tRNAs. The protein also interacts with activated Smad family member 2 (Smad2) and its nuclear partner forkhead box H1 (also known as FAST-1), and reduced expression can suppress transforming growth factor-beta induced growth arrest. Mutations in this gene result in an increased risk of prostate cancer. Multiple transcript variants encoding different isoforms have been found for this gene.
• Source: HEK293
• Species: Human
• Tag: Myc&DDK
• Molecular Mass: 92.2 kDa
• AA Sequence: MWALCSLLRSAAGRTMSQGRTISQA PARRERPRKDPLRHLRTREKRGPSG CSGGPNTVYLQVVAAGSRDSGAALY VFSEFNRYLFNCGEGVQRLMQEHKL KVARLDNIFLTRMHWSNVGGLSGMI LTLKETGLPKCVLSGPPQLEKYLEA IKIFSGPLKGIELAVRPHSAPEYED ETMTVYQIPIHSEQRRGKHQPWQSP ERPLSRLSPERSSDSELNENEPHLP HGVSQRRGVRDSSLVVAFICKLHLK RGNFLVLKAKEMGLPVGTAAIAPII AAVKDGKSITHEGREILAEELCTPP DPGAAFVVVECPDESFIQPICENAT FQRYQGKADAPVALVVHMAPASVLV DSRYQQWMERFGPDTQHLVLNENCA SVHNLRSHKIQTQLNLIHPDIFPLL TSFRCKKEGPTLSVPMVQGECLLKY QLRPRREWQRDAIITCNPEEFIVEA LQLPNFQQSVQEYRRSAQDGPAPAE KRSQYPEIIFLGTGSAIPMKIRNVS ATLVNISPDTSLLLDCGEGTFGQLC RHYGDQVDRVLGTLAAVFVSHLHAD HHTGLPSILLQRERALASLGKPLHP LLVVAPNQLKAWLQQYHNQCQEVLH HISMIPAKCLQEGAEISSPAVERLI SSLLRTCDLEEFQTCLVRHCKHAFG CALVHTSGWKVVYSGDTMPCEALVR MGKDATLLIHEATLEDGLEEEAVEK THSTTSQAISVGMRMNAEFIMLNHF SQRYAKVPLFSPNFSEKVGVAFDHM KVCFGDFPTMPKLIPPLKALFAGDI EEMEERREKRELRQVRAALLSRELA GGLEDGEPQQKRAHTEEPQAKKVRA QTRTRPLEQKLISEEDLAANDILDY KDDDDKV
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining
• Stability: Stable for 3 months from receipt of products under proper storage and handling conditions.
• Storage: Store at -80 centigrade. Avoid repeated freeze-thaw cycles.
• Concentration: 50 μg/mL as determined by BCA
• Storage Buffer: 100 mM glycine, 25 mM Tris-HCl, pH 7.3.

Gene Information

• Gene Name: ELAC2 elaC ribonuclease Z 2 [ Homo sapiens (human) ]
• Official Symbol: ELAC2
• Synonyms: ELAC2; elaC homolog 2 (E. coli); elaC (E. coli) homolog 2; zinc phosphodiesterase ELAC protein 2; FLJ10530; HPC2; tRNase Z (long form); RNase Z 2; tRNase Z 2; ribonuclease Z 2; tRNA 3 endonuclease 2; elaC homolog protein 2; heredity prostate cancer protein 2; putative prostate cancer susceptibility protein HPC2/ELAC2; ELC2; FLJ36693; FLJ42848
• Gene ID: 60528
• mRNA Refseq: NM_018127
• Protein Refseq: NP_060597
• MIM: 605367
• UniProt ID: Q9BQ52