Recombinant Human EDN3, GST-tagged

• Cat.No.: EDN3-12284H
• Product Overview: Recombinant Human EDN3 protein, fused to GST-tag, was expressed in E.coli and purified by GSH-sepharose.

Specification

• Species: Human
• Source: E.coli
• Tag: GST
• Protein Length: 1-238a.a.
• Description: The protein encoded by this gene is a member of the endothelin family. Endothelins are endothelium-derived vasoactive peptides involved in a variety of biological functions. The active form of this protein is a 21 amino acid peptide processed from the precursor protein. The active peptide is a ligand for endothelin receptor type B (EDNRB). The interaction of this endothelin with EDNRB is essential for development of neural crest-derived cell lineages, such as melanocytes and enteric neurons. Mutations in this gene and EDNRB have been associated with Hirschsprung disease (HSCR) and Waardenburg syndrome (WS), which are congenital disorders involving neural crest-derived cells. Four alternatively spliced transcript variants encoding three distinct isoforms have been observed.
• Storage: The protein is stored in PBS buffer at -20℃. Avoid repeated freezing and thawing cycles.
• Storage Buffer: 1M PBS (58mM Na2HPO4,17mM NaH2PO4, 68mM NaCl, pH8. ) added with 100mM GSH and 1% Triton X-100,15%glycerol.

Gene Information

• Gene Name: EDN3 endothelin 3 [ Homo sapiens ]
• Official Symbol: EDN3
• Synonyms: EDN3; endothelin 3; endothelin-3; ET3; preproendothelin-3; ET-3; WS4B; HSCR4; PPET3; MGC15067; MGC61498
• Gene ID: 1908
• mRNA Refseq: NM_000114
• Protein Refseq: NP_000105
• MIM: 131242
• UniProt ID: P14138
• Chromosome Location: 20q13.2-q13.3
• Pathway: Class A/1 (Rhodopsin-like receptors), organism-specific biosystem; Endothelins, organism-specific biosystem; G alpha (q) signalling events, organism-specific biosystem; GPCR downstream signaling, organism-specific biosystem; GPCR ligand binding, organism-specific biosystem; Peptide ligand-binding receptors, organism-specific biosystem; Signal Transduction, organism-specific biosystem
• Function: endothelin B receptor binding; hormone activity; receptor binding