Recombinant Human DYX1C1, His-tagged

• Cat.No.: DYX1C1-12242H
• Product Overview: Recombinant Human DYX1C1 protein, fused to His-tag, was expressed in E.coli and purified by Ni-sepharose.

Specification

• Species: Human
• Source: E.coli
• Tag: His
• Protein Length: 1-381a.a.
• Description: This gene encodes a tetratricopeptide repeat domain-containing protein. The encoded protein interacts with estrogen receptors and the heat shock proteins, Hsp70 and Hsp90. An homologous protein in rat has been shown to function in neuronal migration in the developing neocortex. A chromosomal translocation involving this gene is associated with a susceptibility to developmental dyslexia. Mutations in this gene are associated with deficits in reading and spelling. Alternative splicing results in multiple transcript variants. Read-through transcription also exists between this gene and the downstream cell cycle progression 1 (CCPG1) gene.
• Storage: The protein is stored in PBS buffer at -20℃. Avoid repeated freezing and thawing cycles.
• Storage Buffer: 1M PBS (58mM Na2HPO4,17mM NaH2PO4, 68mM NaCl, pH8. ) added with 300mM Imidazole and 0.7% Sarcosyl, 15%glycerol.

Gene Information

• Gene Name: DYX1C1 dyslexia susceptibility 1 candidate 1 [ Homo sapiens ]
• Official Symbol: DYX1C1
• Synonyms: DYX1C1; dyslexia susceptibility 1 candidate 1; dyslexia susceptibility 1 candidate gene 1 protein; EKN1; FLJ37882; RD; DYX1; DYXC1; MGC70618
• Gene ID: 161582
• mRNA Refseq: NM_001033559
• Protein Refseq: NP_001028731
• MIM: 608706
• UniProt ID: Q8WXU2
• Chromosome Location: 15q21.1
• Function: estrogen receptor binding; protein binding