Recombinant Human Dynein, Light Chain, LC8-Type 2, His-tagged

• Cat.No.: DYNLL2-4997H
• Product Overview: Recombinant humanDYNLL2 protein, fused to His-tag at N-terminus, was expressed in E. coli andpurified by using conventional chromatography techniques.

Specification

• Cat. No.: DYNLL2-4997H
• Description: Dynein light chain2, cytoplasmic, also known DYNLL2, is a large protein complex composed of sixdistinct subunits and is responsible for most intracellular movement towardthe minus ends of microtubules. Dyneins are multisubunit, high molecularweight ATPases that interact with microtubules to generate force byconverting the chemical energy of ATP into the mechanical energy of movement.DYNLL2 is a highly conserved eukaryotic hub protein with dozens of bindingpartners and various functions beyond being a subunit of dynein and myosin Vamotor proteins.
• Concentration: 1 mg/ml
• Source: Human
• Host: E. coli
• Form: Supplied as a liquidin 20 mM Tris-HCl buffer, pH 8.0, containing 1 mM DTT, 30% glycerol and 0.2 MNaCl.
• Purity: > 90% by SDS-PAGE
• Sequence: 1-89 amino acids:MGSSHHHHHH SSGLVPRGSH MSDRKAVIKN ADMSEDMQQD AVDCATQAME KYNIEKDIAA YIKKEFDKKYNPTWHCIVGR NFGSYVTHET KHFIYFYLGQ VAILLFKSG
• Molecular Mass: 12.5 kDa (109 aa),confirmed by MALDI-TOF.
• Applications: SDS-PAGE
• Storage: Store at 4 deg C forshort term storage (1/2 weeks). Aliquot and store at -20 deg C or -70 deg Cfor long term storage. Avoid repeated freeze/thaw cycles.
• OfficialSymbol: DYNLL2
• Function: cytoskeletal proteinbinding; motor activity

Gene Information

• Gene Name: DYNLL2 dynein, light chain,LC8-type 2 [ Homo sapiens ]
• Synonyms: DYNLL2; dynein,light chain, LC8-type 2; Dlc2; DNCL1B; RSPH22; MGC17810; dynein light chain2, cytoplasmic; DLC8b; radial spoke 22 homolog; 8 kDa dynein light chain b;radial spoke 22 homolog (Chlamydomonas); Dynein light chain 2, cytoplasmic;Dynein light chain LC8-type 2; DLC2
• Gene ID: 140735
• mRNA Refseq: NM_080677
• Protein Refseq: NP_542408
• MIM: 608942
• UniProt ID: Q96FJ2
• Chromosome Location: 17q22
• Pathway: Activation ofBH3-only proteins; Activation of BMF and translocation to mitochondria;Apoptosis; Intrinsic Pathway for Apoptosis; Vasopressin-regulated waterreabsorption