Recombinant Human DYNC1I2, GST-tagged

• Cat.No.: DYNC1I2-12227H
• Product Overview: Recombinant Human DYNC1I2 protein, fused to GST-tag, was expressed in E.coli and purified by GSH-sepharose.

Specification

• Species: Human
• Source: E.coli
• Tag: GST
• Protein Length: C-term-309a.a.
• Description: This gene encodes a member of the dynein intermediate chain family. The encoded protein is a non-catalytic component of the cytoplasmic dynein 1 complex, which acts as a retrograde microtubule motor to transport organelles and vesicles. A pseudogene of this gene is located on chromosome 10. Alternative splicing results in multiple transcript variants.
• Storage: The protein is stored in PBS buffer at -20℃. Avoid repeated freezing and thawing cycles.
• Storage Buffer: 1M PBS (58mM Na2HPO4,17mM NaH2PO4, 68mM NaCl, pH8. ) added with 100mM GSH and 1% Triton X-100,15%glycerol.

Gene Information

• Gene Name: DYNC1I2 dynein, cytoplasmic 1, intermediate chain 2 [ Homo sapiens ]
• Official Symbol: DYNC1I2
• Synonyms: DYNC1I2; dynein, cytoplasmic 1, intermediate chain 2; DNCI2, dynein, cytoplasmic, intermediate polypeptide 2; cytoplasmic dynein 1 intermediate chain 2; DH IC-2; dynein intermediate chain 2, cytosolic; cytoplasmic dynein intermediate chain 2; dynein, cytoplasmic, intermediate polypeptide 2; IC2; DNCI2; MGC9324; FLJ21089; FLJ90842; MGC104199; MGC111094
• Gene ID: 1781
• mRNA Refseq: NM_001378
• Protein Refseq: NP_001369
• MIM: 603331
• UniProt ID: Q13409
• Chromosome Location: 2q31.1
• Pathway: Cell Cycle, organism-specific biosystem; Cell Cycle, Mitotic, organism-specific biosystem; Centrosome maturation, organism-specific biosystem; G2/M Transition, organism-specific biosystem; Loss of Nlp from mitotic centrosomes, organism-specific biosystem; Loss of proteins required for interphase microtubule organization??from the centrosome, organism-specific biosystem; Mitotic G2-G2/M phases, organism-specific biosystem
• Function: microtubule motor activity