Recombinant Human DUSP19, His-tagged

• Cat.No.: DUSP19-28073TH
• Product Overview: DUSP19, 65-217aa, Human, His tag, E.coli

Specification

• Species: Human
• Tag: His
• Protein Length: 65-217 a.a.
• Description: Dual-specificity phosphatases (DUSPs) constitute a large heterogeneous subgroup of the type I cysteine-based protein-tyrosine phosphatase superfamily. DUSPs are characterized by their ability to dephosphorylate both tyrosine and serine/threonine residues. They have been implicated as major modulators of critical signaling pathways. DUSP19 contains a variation of the consensus DUSP C-terminal catalytic domain, with the last serine residue replaced by alanine, and lacks the N-terminal CH2 domain found in the MKP (mitogen-activated protein kinase phosphatase) class of DUSPs (see MIM 600714) (summary by Patterson et al.
• Conjugation: HIS
• Tissue specificity: Expressed in the heart, lung, liver, and pancreas. The expression level in the pancreas is the highest.
• Purity: >90% by SDS-PAGE
• Sequence Similarities: Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily.Contains 1 tyrosine-protein phosphatase domain.

Gene Information

• Gene Name: DUSP19 dual specificity phosphatase 19 [ Homo sapiens ]
• Official Symbol: DUSP19
• Synonyms: DUSP19; dual specificity phosphatase 19; dual specificity protein phosphatase 19; DUSP17; SKRP1
• Gene ID: 142679
• mRNA Refseq: NM_080876
• Protein Refseq: NP_543152
• MIM: 611437
• Uniprot ID: Q8WTR2
• Chromosome Location: 2q32.1
• Function: JUN kinase phosphatase activity; MAP-kinase scaffold activity; hydrolase activity; mitogen-activated protein kinase kinase kinase binding; protein kinase activator activity