DUSP19
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Official Full Name
dual specificity phosphatase 19 -
Overview
Dual-specificity phosphatases (DUSPs) constitute a large heterogeneous subgroup of the type I cysteine-based;protein-tyrosine phosphatase superfamily. DUSPs are characterized by their ability to dephosphorylate both tyrosine;and serine/threonine residues. They have been implicated as major modulators of critical signaling pathways. DUSP19;contains a variation of the consensus DUSP C-terminal catalytic domain, with the last serine residue replaced by;alanine, and lacks the N-terminal CH2 domain found in the MKP (mitogen-activated protein kinase phosphatase) class of;DUSPs (see MIM 600714) (summary by Patterson et al., 2009 (PubMed 19228121)). -
Synonyms
DUSP19;dual specificity phosphatase 19;dual specificity protein phosphatase 19;DUSP17;SKRP1;Dual specificity phosphatase TS DSP1;Dual specificity phosphatase TS-DSP1;DUS19_HUMAN;DUSP 17;DUSP 19;LMW DSP3;LMW-DSP3;LMWDSP 3;LMWDSP3;Low molecular weight dual specificity phosphatase 3;MGC138210;Protein phosphatase SKRP1;SAPK pathway regulating phosphatase 1;SAPK pathway-regulating phosphatase 1;SKRP 1;Stress activated protein kinase pathway regulating phosphatase 1;Stress-activated protein kinase pathway-regulating phosphatase 1;TS DSP1;TS-DSP1
Recombinant Proteins
- Human
- Rhesus macaque
- Mouse
- E.coli
- Mammalian Cells
- Wheat Germ
- HEK293
- In Vitro Cell Free System
- GST
- His
- Non
- His&Fc&Avi
- Myc&DDK
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| DUSP19-12211H | Recombinant Human DUSP19, GST-tagged | E.coli | Human | GST | 1-217a.a. | |
| DUSP19-1317H | Recombinant Human Dual Specificity Phosphatase 19, His-tagged | E.coli | Human | His |
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| DUSP19-1351R | Recombinant Rhesus monkey DUSP19 Protein, His-tagged | Mammalian Cells | Rhesus macaque | His |
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| DUSP19-28073TH | Recombinant Human DUSP19, His-tagged | Human | His | 65-217 a.a. |
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| DUSP19-2932H | Recombinant Human DUSP19 Protein, GST-tagged | Wheat Germ | Human | GST |
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| DUSP19-6779HCL | Recombinant Human DUSP19 293 Cell Lysate | HEK293 | Human | Non |
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| DUSP19-1176R | Recombinant Rhesus Macaque DUSP19 Protein, His (Fc)-Avi-tagged | HEK293 | Rhesus macaque | His&Fc&Avi |
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| DUSP19-1176R-B | Recombinant Rhesus Macaque DUSP19 Protein Pre-coupled Magnetic Beads | HEK293 | Rhesus macaque |
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| Dusp19-2686M | Recombinant Mouse Dusp19 Protein, Myc/DDK-tagged | HEK293 | Mouse | Myc&DDK |
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| DUSP19-4100HF | Recombinant Full Length Human DUSP19 Protein, GST-tagged | In Vitro Cell Free System | Human | GST | Full L. 217 amino acids |
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Involved Pathway
DUSP19 involved in several pathways and played different roles in them. We selected most pathways DUSP19 participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with DUSP19 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|
Protein Function
DUSP19 has several biochemical functions, for example, JUN kinase phosphatase activity,MAP-kinase scaffold activity,mitogen-activated protein kinase kinase kinase binding. Some of the functions are cooperated with other proteins, some of the functions could acted by DUSP19 itself. We selected most functions DUSP19 had, and list some proteins which have the same functions with DUSP19. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| mitogen-activated protein kinase kinase kinase binding | TCF3,CDC37,MAP3K11,STK38,PPEF2,MAPK9,MAP4K2,MAPK1,MAP2K1,MAPK8IP3 |
| protein kinase inhibitor activity | SOCS5B,SH3BP5L,TRIB2,SOCS9,SOCS1,SH3BP5,JIP1,SOCS6B,CHP,SOCS3A |
| protein tyrosine phosphatase activity | CDC25B,PTPRJ,MTMR1B,PTPRF,DUSP2,PTPN2,DUSP15,EYA4,DUSP8A,PTPRQ |
| protein binding | STXBP3A,FOXM1,YIPF4,GSK3B,WFDC9,ERLEC1,FAM96B,RRAD,TMEM139,DYNC1I2 |
| JUN kinase phosphatase activity | CTDSPL2B,TENC1,SACM1LA,PTPRQ,CTDSPL2A,SGPP2,SACM1L,SACM1LB,NT5DC3,PXYLP1 |
| protein tyrosine/threonine phosphatase activity | SACM1L,NT5DC3,CTDSPL2B,DUSP2,PTPRQ,SACM1LA,PXYLP1,DUSP1,TENC1,CTDSPL2A |
| MAP-kinase scaffold activity | KSR1,MAPK8IP2,CD36,SPAG9A,MAPK8IP3,SPAG9,JIP1 |
| protein kinase activator activity | CAB39,NKX3-1,FGF13,GPRC5B,EPO,PIK3CA,MARK2,TOM1L1,PRKAG2,NCKAP1L |
Interacting Protein
DUSP19 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with DUSP19 here. Most of them are supplied by our site. Hope this information will be useful for your research of DUSP19.
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References
- Ma, JJ; Yu, XY; et al. DUSP6, a tumor suppressor, is involved in differentiation and apoptosis in esophageal squamous cell carcinoma. ONCOLOGY LETTERS 6:1624-1630(2013).
- Cagnol, S; Rivard, N; et al. Oncogenic KRAS and BRAF activation of the MEK/ERK signaling pathway promotes expression of dual-specificity phosphatase 4 (DUSP4/MKP2) resulting in nuclear ERK1/2 inhibition. ONCOGENE 32:564-576(2013).
