Recombinant Human DUSP19, GST-tagged

• Cat.No.: DUSP19-12211H
• Product Overview: Recombinant Human DUSP19 protein, fused to GST-tag, was expressed in E.coli and purified by GSH-sepharose.

Specification

• Species: Human
• Source: E.coli
• Tag: GST
• Protein Length: 1-217a.a.
• Description: Dual-specificity phosphatases (DUSPs) constitute a large heterogeneous subgroup of the type I cysteine-based protein-tyrosine phosphatase superfamily. DUSPs are characterized by their ability to dephosphorylate both tyrosine and serine/threonine residues. They have been implicated as major modulators of critical signaling pathways. DUSP19 contains a variation of the consensus DUSP C-terminal catalytic domain, with the last serine residue replaced by alanine, and lacks the N-terminal CH2 domain found in the MKP (mitogen-activated protein kinase phosphatase) class of DUSPs (see MIM 600714) (summary by Patterson et al., 2009 [PubMed 19228121]).
• Storage: The protein is stored in PBS buffer at -20℃. Avoid repeated freezing and thawing cycles.
• Storage Buffer: 1M PBS (58mM Na2HPO4,17mM NaH2PO4, 68mM NaCl, pH8. ) added with 100mM GSH and 1% Triton X-100,15%glycerol.

Gene Information

• Gene Name: DUSP19 dual specificity phosphatase 19 [ Homo sapiens ]
• Official Symbol: DUSP19
• Synonyms: DUSP19; dual specificity phosphatase 19; dual specificity protein phosphatase 19; DUSP17; SKRP1; LMW-DSP3; protein phosphatase SKRP1; dual specificity phosphatase TS-DSP1; SAPK pathway-regulating phosphatase 1; low molecular weight dual specificity phosphatase 3; stress-activated protein kinase pathway-regulating phosphatase 1; LMWDSP3; TS-DSP1; MGC138210
• Gene ID: 142679
• mRNA Refseq: NM_001142314
• Protein Refseq: NP_001135786
• MIM: 611437
• UniProt ID: Q8WTR2
• Chromosome Location: 2q32.1
• Function: JUN kinase phosphatase activity; MAP-kinase scaffold activity; hydrolase activity; mitogen-activated protein kinase kinase kinase binding; protein kinase activator activity; protein kinase inhibitor activity; protein tyrosine phosphatase activity; protein