Recombinant Human DSG1

• Cat.No.: DSG1-8319H
• Product Overview: Recombinant Human DSG1 was expressed in NSO Cells.

Specification

• Species: Human
• Source: Mammalian Cells
• Tag: Non
• Description: Desmoglein 1, also known as DSG1, is a human gene. Desmosomes are cell-cell junctions between epithelial, myocardial and certain other cell types. Desmoglein 1 is a calcium-binding transmembrane glycoprotein component of desmosomes in vertebrate epithelial cells. Currently, three desmoglein subfamily members have been identified and all are members of the cadherin cell adhesion molecule superfamily. DGI expression may be a significant factor for invasion, metastasis, and prognosis of human esophageal cancer.
• Form: This recombinant protein was 0.2 μm filtered and lyophilized from modified Dulbecco's phosphate buffered saline (1X PBS) pH 7.2 – 7.3 with no calcium, magnesium, or preservatives.
• Molecular Mass: The predicted molecular weight of Recombinant Human Desmoglein-1 is Mr 82 kDa. However, the actual molecular weight as observed by migration on SDS-PAGE is Mr 110 kDa.
• AA Sequence: whsirrqkre wikfaaacre gednskrnpi akihsdcaan qqvtyrisgv gidqppygif vinqktgein itsivdrevt pffiiycral nsmgqdlerp lelrvrvldi ndnppvfsma tfagqieens nantlvmiln atdadepnnl nskiafkiir qepsdspmfi inrntgeirt mnnfldreqy gqyalavrgs drdggadgms aececnikil dvndnipyme qssytieiqe ntlnsnllei rvidldeefs anwmaviffi sgnegnwfei emnertnvgi lkvvkpldye amqslqlsig vrnkaefhhs imsqyklkas aisvtvlnvi egpvfrpgsk tyvvtgnmgs ndkvgdfvat dldtgrpstt vryvmgnnpa dllavdsrtg kltlknkvtk eqynmlggky qgtilsiddn lqrtctgtin iniqsfgndd rtntepntki ttntgrqest sstnydtstt stdssqvyss epgngakdll sdnvhkscdk thtcppcpap ellggpsvfl fppkpkdtlm isrtpevtcv vvdvshedpe vkfnwyvdgv evhnaktkpr eeqynstyrv vsvltvlhqd wlngkeykck vsnkalpapi ektiskakgq prepqvytlp psrdeltknq vsltclvkgf ypsdiavewe sngqpennyk ttppvldsdg sfflyskltv dksrwqqgnv fscsvmheal hnhytqksls lspgk
• Endotoxin: <1.0 eu/μg="" as="" determined="" by="" the="" lal="">
• Purity: >95% by SDS-PAGE and analyzed by silver stain.
• Storage: This lyophilized protein is stable for six to twelve months when stored desiccated at -20°C to -70°C. After aseptic reconstitution, this protein may be stored at 2°C to 8°C for one month or at -20°C to -70°C in a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles.

Gene Information

• Gene Name: DSG1 desmoglein 1 [ Homo sapiens ]
• Official Symbol: DSG1
• Synonyms: DSG1; desmoglein 1; DSG; desmoglein-1; CDHF4; DGI; cadherin family member 4; desmosomal glycoprotein 1; pemphigus foliaceus antigen; DG1; PPKS1; SPPK1
• Gene ID: 1828
• mRNA Refseq: NM_001942
• Protein Refseq: NP_001933
• MIM: 125670
• UniProt ID: Q02413
• Chromosome Location: 18q12.1
• Pathway: Apoptosis, organism-specific biosystem; Apoptotic cleavage of cell adhesionproteins, organism-specific biosystem; Apoptotic cleavage of cellular proteins, organism-specific biosystem; Apoptotic executionphase, organism-specific biosystem; Staphylococcus aureus infection, organism-specific biosystem; Staphylococcus aureus infection, conserved biosystem
• Function: calcium ion binding; gamma-catenin binding; toxin binding