Recombinant Human DSG1

• Cat.No.: DSG1-26581TH
• Product Overview: Recombinant full length Human Desmoglein 1 with N terminal proprietary tag; Predicted MWt 142.39 kDa inclusive of tag.

Specification

• Description: Desmosomes are cell-cell junctions between epithelial, myocardial and certain other cell types. Desmoglein 1 is a calcium-binding transmembrane glycoprotein component of desmosomes in vertebrate epithelial cells. Currently, three desmoglein subfamily members have been identified and all are members of the cadherin cell adhesion molecule superfamily. These desmoglein gene family members are located in a cluster on chromosome 18. The protein encoded by this gene has been identified as the autoantigen of the autoimmune skin blistering disease pemphigus foliaceus.
• Protein length: 1049 amino acids
• Molecular Weight: 142.390kDa inclusive of tags
• Source: Wheat germ
• Tissue specificity: Epidermis, tongue, tonsil and esophagus.
• Form: Liquid
• Purity: Proprietary Purification
• Storage buffer: pH: 8.00Constituents:0.3% Glutathione, 0.79% Tris HCl
• Storage: Shipped on dry ice. Upon delivery aliquot and store at -80oC. Avoid freeze / thaw cycles.
• Sequences of amino acids: MDWSFFRVVAMLFIFLVVVEVNSEFRIQVRDYNTKNGTIK WHSIRRQKREWIKFAAACREGEDNSKRNPIAKIHSDCAAN QQVTYRISGVGIDQPPYGIFVINQKTGEINITSIVDREVT PFFIIYCRALNSMGQDLERPLELRVRVLDINDNPPVFSMA TFAGQIEENSNANTLVMILNATDADEPNNLNSKIAFKIIR QEPSDSPMFIINRNTGEIRTMNNFLDREQYGQYALAVRGS DRDGGADGMSAECECNIKILDVNDNIPYMEQSSYTIEIQE NTLNSNLLEIRVIDLDEEFSANWMAVIFFISGNEGNWFEI EMNERTNVGILKVVKPLDYEAMQSLQLSIGVRNKAEFHHS IMSQYKLKASAISVTVLNVIEGPVFRPGSKTYVVTGNMGS NDKVGDFVATDLDTGRPSTTVRYVMGNNPADLLAVDSRTG KLTLKNKVTKEQYNMLGGKYQGTILSIDDNLQRTCTGTIN INIQSFGNDDRTNTEPNTKITTNTGRQESTSSTNYDTSTT STDSSQVYSSEPGNGAKDLLSDNVHFGPAGIGLLIMGFLV LGLVPFLMICCDCGGAPRSAAGFEPVPECSDGAIHSWAVE GPQPEPRDITTVIPQIPPDNANIIECIDNSGVYTNEYGGR EMQDLGGGERMTGFELTEGVKTSGMPEICQEYSGTLRRNS MRECREGGLNMNFMESYFCQKAYAYADEDEGRPSNDCLLI YDIEGVGSPAGSVGCCSFIGEDLDDSFLDTLGPKFKKLAD ISLGKESYPDLDPSWPPQSTEPVCLPQETEPVVSGHPPIS PHFGTTTVISESTYPSGPGVLHPKPILDPLGYGNVTVTES YTTSDTLKPSVHVHDNRPASNVVVTERVVGPISGADLHGM LEMPDLRDGSNVIVTERVIAPSSSLPTSLTIHHPRESSNV VVTERVIQPTSGMIGSLSMHPELANAHNVIVTERVVSGAG VTGISGTTGISGGIGSSGLVGTSMGAGSGALSGAGISGGG IGLSSLGGTASIGHMRSSSDHHFNQTIGSASPSTARSRIT KYSTVQYSK
• Sequence Similarities: Contains 4 cadherin domains.
• Tag: Non

Gene Information

• Gene Name: DSG1 desmoglein 1 [ Homo sapiens ]
• Official Symbol: DSG1
• Synonyms: DSG1; desmoglein 1; DSG; desmoglein-1; CDHF4
• Gene ID: 1828
• mRNA Refseq: NM_001942
• Protein Refseq: NP_001933
• MIM: 125670
• Uniprot ID: Q02413
• Chromosome Location: 18q12.1
• Pathway: Apoptosis, organism-specific biosystem; Apoptotic cleavage of cell adhesionproteins, organism-specific biosystem; Apoptotic cleavage of cellular proteins, organism-specific biosystem; Apoptotic executionphase, organism-specific biosystem; Staphylococcus aureus infection, organism-specific biosystem
• Function: calcium ion binding; gamma-catenin binding; toxin binding