Recombinant Human DRG1, His-tagged

• Cat.No.: DRG1-3558H
• Product Overview: Recombinant human DRG1 protein, fused to His-tag at N-terminus, was expressed in E.coli and purified by using conventional chromatography techniques (1-367aa).

Specification

• Species: Human
• Source: E.coli
• Tag: His
• Description: Developmentally-regulated GTP-binding protein 1(DRG1) belong to the GTP1/OBG family. It plays a role in cell proliferation and differentiation, as well as in apoptosis, suggesting a role in tumor formation and metastasis. Expression of the DRG1 was significantly reduced in breast tumor cells, particularly in patients with lymph node or bone metastasis as compared to those with localized breast cancer. This protein expressed at high levels in heart, kidney and skeletal muscle and at lower levels in brain, liver, placenta, lung, colon and spleen.
• Form: Liquid. In 20mM Tris-HCl buffer (pH 8.0) containing 1mM DTT, 30% glycerol, 1mM EDTA.
• Molecular Weight: 42.7kDa (387aa), confirmed by MALDI-TOF
• Purity: > 85% by SDS - PAGE
• Concentration: 0.5 mg/ml (determined by Bradford assay)
• Sequences Of Amino Acids: MGSSHHHHHH SSGLVPRGSH MSSTLAKIAE IEAEMARTQK NKATAHHLGL LKARLAKLRR ELITPKGGGG GGPGEGFDVA KTGDARIGFV GFPSVGKSTL LSNLAGVYSE VAAYEFTTLT TVPGVIRYKG AKIQLLDLPG IIEGAKDGKG RGRQVIAVAR TCNLILIVLD VLKPLGHKKI IENELEGFGI RLNSKPPNIG FKKKDKGGIN LTATCPQSEL DAETVKSILA EYKIHNADVT LRSDATADDL IDVVEGNRVY IPCIYVLNKI DQISIEELDI IYKVPHCVPI SAHHRWNFDD LLEKIWDYLK LVRIYTKPKG QLPDYTSPVV LPYSRTTVED FCMKIHKNLI KEFKYALVWG LSVKHNPQKV GKDHTLEDED VIQIVKK.
• Storage: Can be stored at +4°C short term (1-2 weeks). For long term storage, aliquot and store at -20°C or -70°C. Avoid repeated freezing and thawing cycles.

Gene Information

• Gene Name: DRG1 developmentally regulated GTP binding protein 1 [ Homo sapiens ]
• Official Symbol: DRG1
• Synonyms: DRG1;developmentally regulated GTP binding protein 1; NEDD3; DKFZp434N1827; developmentally-regulated GTP-binding protein 1; DRG-1; NEDD-3; OTTHUMP0000- 0028883; developmentally regulated GTP-binding protein 1; neural precursor cell expressed, developmentally down-regulated 3; neural precursor cell expressed developmentally down-regulated protein 3; Neural precursor cell expressed developmentally down- regulated protein 3
• Gene ID: 4733
• mRNA Refseq: NM_004147
• Protein Refseq: NP_004138
• MIM: 603952
• UniProt ID: Q9Y295
• Chromosome Location: 22q12.2
• Function: GTP binding; nucleotide binding; protein binding; transcription factor binding