Recombinant Human DPYD Protein, GST-tagged

• Cat.No.: DPYD-2860H
• Product Overview: Human DPYD full-length ORF ( AAH08379, 1 a.a. - 173 a.a.) recombinant protein with GST-tag at N-terminal.

Specification

• Description: The protein encoded by this gene is a pyrimidine catabolic enzyme and the initial and rate-limiting factor in the pathway of uracil and thymidine catabolism. Mutations in this gene result in dihydropyrimidine dehydrogenase deficiency, an error in pyrimidine metabolism associated with thymine-uraciluria and an increased risk of toxicity in cancer patients receiving 5-fluorouracil chemotherapy. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2009]
• Source: Wheat Germ
• Species: Human
• Tag: GST
• Molecular Mass: 44.66 kDa
• AA Sequence: MAPVLSKDSADIESILALNPRTQTHATLCSTSAKKLDKKHWKRNPDKNCFNCEKLENNFDDIKHTTLGERGALREAMRCLKCADAPCQKSCPTNLDIKSFITSIANKNYYGAAKMIFSDNPLGLTCGMVCPTSDLCVGGCNLYATEEGPINIGGLQQFATETLILAFSLMNHL
• Applications: Enzyme-linked Immunoabsorbent Assay
  Western Blot (Recombinant protein)
  Antibody Production
  Protein Array
• Notes: Best use within three months from the date of receipt of this protein.
• Storage: Store at -80 centigrade. Aliquot to avoid repeated freezing and thawing.
• Storage Buffer: 50 mM Tris-HCI, 10 mM reduced Glutathione, pH=8.0 in the elution buffer.

Gene Information

• Gene Name: DPYD dihydropyrimidine dehydrogenase [ Homo sapiens ]
• Official Symbol: DPYD
• Synonyms: DPYD; dihydropyrimidine dehydrogenase; dihydropyrimidine dehydrogenase [NADP(+)]; DPD; dihydrouracil dehydrogenase; dihydrothymine dehydrogenase; DHP; DHPDHASE; MGC70799; MGC132008
• Gene ID: 1806
• mRNA Refseq: NM_000110
• Protein Refseq: NP_000101
• MIM: 612779
• UniProt ID: Q12882