DPYD
-
Official Full Name
dihydropyrimidine dehydrogenase -
Overview
The protein encoded by this gene is a pyrimidine catabolic enzyme and the initial and rate-limiting factor in the pathway of uracil and thymidine catabolism. Mutations in this gene result in dihydropyrimidine dehydrogenase deficiency, an error in pyrimidine metabolism associated with thymine-uraciluria and an increased risk of toxicity in cancer patients receiving 5-fluorouracil chemotherapy. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2009] -
Synonyms
DPYD;dihydropyrimidine dehydrogenase;DHP;DPD;DHPDHASE;dihydropyrimidine dehydrogenase [NADP(+)];dihydrouracil dehydrogenase;dihydrothymine dehydrogenase
Recombinant Proteins
- Human
- Rat
- Mouse
- E.coli
- Mammalian Cell
- Wheat Germ
- HEK293T
- HEK293
- In Vitro Cell Free System
- Mammalian cells
- His
- GST
- His&T7
- Non
- Myc&DDK
- His&Fc&Avi
- Flag
Involved Pathway
DPYD involved in several pathways and played different roles in them. We selected most pathways DPYD participated on our site, such as Drug metabolism - other enzymes,Fluoropyrimidine Activity,Metabolic pathways, which may be useful for your reference. Also, other proteins which involved in the same pathway with DPYD were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Metabolism of nucleotides | DUT,ADAL,NUDT18,PAICS,PNP5B,DPYS,TYMP,ADSS,UPP2,DTYMK |
| Pyrimidine catabolism | DPYDA.1,UPP2,PROZA,DPYS,TYMP |
| Fluoropyrimidine Activity | UPP2,CES1,TYMP,DPYS,DHFR,SLC22A7 |
| Pyrimidine metabolism | POLR2G,NT5C,TYMP,TXNRD1,DCK,PNPT1,NME3,CANT1,POLR2C,POLR3D |
| Metabolic pathways | Acsm2a,HSD17B8,MGAT1,CYP4F2,PNLIPRP1,MOGAT3,NDUFA12,B3GNTL2,AOX1,CHKA |
| Drug metabolism - other enzymes | UMPS,NAT1,UGT1A7,UGT1A4,UCK2A,Ces2c,IMPDH2,UCK1,HPRT1,UCK2B |
| Metabolism | KHK,DUT,KCNJ11,GPHNA,CYB5A,AKR1C6,NUDT15,COX6A1,CTRC,ITPKB |
| Pantothenate and CoA biosynthesis | PANK1B,AASDHPPT,VNN2,UPB1,DPYDB,PANK1,PANK4,VNN1,ENPP3,BCAT1 |
Protein Function
DPYD has several biochemical functions, for example, 4 iron, 4 sulfur cluster binding,NADP binding,dihydropyrimidine dehydrogenase (NADP+) activity. Some of the functions are cooperated with other proteins, some of the functions could acted by DPYD itself. We selected most functions DPYD had, and list some proteins which have the same functions with DPYD. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein homodimerization activity | PLD6,HPGD,PTPRO,CUBN,TIMM9,EXT1,IRF3,RAB11FIP4A,DMRTC1C2,ROPN1B |
| NADP binding | FMO5,G6PD,GAPDHS,FMO1,MIOX,SPR,FMO3,H6PD,POR,CAT |
| flavin adenine dinucleotide binding | ETFA,ACAD9,LDHD,MAOA,AIFM3,DLDH,KMO,ACOX1,DUS3L,IVD |
| dihydropyrimidine dehydrogenase (NADP+) activity | DPYDB |
| metal ion binding | IDO1,TGM2,ZNFL2A,ENPP5,MKRN4,MOBKL1A,ZFP146,NEK8,TNNI1,CYP2AA6 |
| protein binding | NKRF,PLXDC1,HOXA10,CLN6,SDHAF2,COMMD7,CSRP3,HARS2,PYCRL,FAM124A |
| 4 iron, 4 sulfur cluster binding | LIAS,DNA2,NDUFS7,NDUFS8,NUBPL,RTEL1,ISCU,ISCA1,POLD1,ETFDH |
Interacting Protein
DPYD has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with DPYD here. Most of them are supplied by our site. Hope this information will be useful for your research of DPYD.
LXN;GOPC;fyuA;pelY;gyrA;q7cj40_yerpe;q7cjh7_yerpe;ebgC1;vacB;smc3;yapH;q8d0h5_yerpe;clpA3;phnK;xerC;tcaC1
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