Recombinant Human DOK1

• Cat.No.: DOK1-28084TH
• Product Overview: Recombinant full length Human DOK1 with proprietary tag

Specification

• Description: The protein encoded by this gene is part of a signal transduction pathway downstream of receptor tyrosine kinases. The encoded protein is a scaffold protein that helps form a platform for the assembly of multiprotein signaling complexes. Two transcript variants encoding different isoforms have been found for this gene.
• Protein length: 481 amino acids
• Molecular Weight: 78.980kDa
• Source: Wheat germ
• Tissue specificity: Expressed in pancreas, heart, leukocyte and spleen. Expressed in both resting and activated peripheral blood T-cells.
• Biological activity: useful for Antibody Production and Protein Array
• Form: Liquid
• Purity: Proprietary Purification
• Storage buffer: pH: 8.00Constituents:0.79% Tris HCl, 0.31% GlutathioneNote: Reduced glutathione
• Storage: Shipped on dry ice. Upon delivery aliquot and store at -80oC. Avoid freeze / thaw cycles.
• Sequence Similarities: Belongs to the DOK family. Type A subfamily.Contains 1 IRS-type PTB domain.Contains 1 PH domain.
• Tag: Non

Gene Information

• Gene Name: DOK1 docking protein 1, 62kDa (downstream of tyrosine kinase 1) [ Homo sapiens ]
• Official Symbol: DOK1
• Synonyms: DOK1; docking protein 1, 62kDa (downstream of tyrosine kinase 1); docking protein 1, 62kD (downstream of tyrosine kinase 1); docking protein 1; p62dok
• Gene ID: 1796
• mRNA Refseq: NM_001197260
• Protein Refseq: NP_001184189
• MIM: 602919
• Uniprot ID: Q99704
• Chromosome Location: 2p13
• Pathway: B Cell Receptor Signaling Pathway, organism-specific biosystem; BCR signaling pathway, organism-specific biosystem; Fc-epsilon receptor I signaling in mast cells, organism-specific biosystem; IRS activation, organism-specific biosystem; IRS-mediated signalling, organism-specific biosystem
• Function: insulin receptor binding; receptor signaling protein activity