DOK1
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Official Full Name
docking protein 1, 62kDa (downstream of tyrosine kinase 1) -
Overview
The protein encoded by this gene is part of a signal transduction pathway downstream of receptor tyrosine kinases. The encoded protein is a scaffold protein that helps form a platform for the assembly of multiprotein signaling complexes. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2010] -
Synonyms
DOK1;docking protein 1, 62kDa (downstream of tyrosine kinase 1);P62DOK;docking protein 1;pp62;p62(dok);Downstream of tyrosine kinase 1;docking protein 1 (downstream of tyrosine kinase 1)
Recombinant Proteins
- Rat
- Human
- Mouse
- Mammalian Cells
- Wheat Germ
- HEK293
- E.coli
- In Vitro Cell Free System
- Guinea Pig
- His
- Non
- SUMO
- Avi
- Fc
- DDK
- Myc
Involved Pathway
DOK1 involved in several pathways and played different roles in them. We selected most pathways DOK1 participated on our site, such as B Cell Receptor Signaling Pathway,BCR signaling pathway,Fc-epsilon receptor I signaling in mast cells, which may be useful for your reference. Also, other proteins which involved in the same pathway with DOK1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Kit Receptor Signaling Pathway | SPRED2B,GRAPA,GRB10,DOK1B,GRAP,PTPRU,STAP1,PTPRUB,GRB7,SOCS4 |
| Measles | CD209B,IFNG,RCHY1,OAS1A,MYD88,STAT3,OAS3,DDX58,TNFRSF10D,OAS1B |
| BCR signaling pathway | MAP4K1,CSNK2A1,MALT1,PAG1,CSK,IBTK,NETO2,POU2F2 |
| B Cell Receptor Signaling Pathway | IGHM,CDK7,DUSP6,PLCG2,ARPC2,CRK,PPP3R1,Cd79a,CD79B,PIK3R1 |
| Insulin Pathway | EXOC6,EXOC5,EXOC1,EXOC3,GRB14,GRB10 |
| Fc-epsilon receptor I signaling in mast cells | ITK,PTPN13,LAT2,S1PR1 |
| Signaling events mediated by PTP1B | YBX1,CSN2,NOX4 |
| PDGFR-beta signaling pathway | GRB10,SLA,SLC9A3R1,SNX15 |
Protein Function
DOK1 has several biochemical functions, for example, insulin receptor binding,protein binding,receptor signaling protein activity. Some of the functions are cooperated with other proteins, some of the functions could acted by DOK1 itself. We selected most functions DOK1 had, and list some proteins which have the same functions with DOK1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| insulin receptor binding | PHIP,FRS2A,ENPP1,PIK3R1,FRS3,INS1,DOK4,PDPK1,IRS2,PTPN11 |
| protein binding | TBC1D10A,CDC42BPG,VENTX,FRMD6,YIF1A,FAM129A,NXF3,CALCA,CDKN2D,NR2F1 |
| receptor signaling protein activity | PLCE1,FLRT1,FLRT3,NGF,DOK4,NSMAF,cgr2b,ARAF,DOK5,ADRB1 |
Interacting Protein
DOK1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with DOK1 here. Most of them are supplied by our site. Hope this information will be useful for your research of DOK1.
SRMS;Cbll1;ORF;CRKL;DOK3;SH2D1A;ERBB2;Dlg4
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References
- Kanehara, K; Cho, Y; et al. Arabidopsis DOK1 encodes a functional dolichol kinase involved in reproduction. PLANT JOURNAL 81:292-303(2015).
- Mukherjee, M; Jing-Song, F; et al. Dimeric Switch of Hakai-truncated Monomers during Substrate Recognition INSIGHTS FROM SOLUTION STUDIES AND NMR STRUCTURE. JOURNAL OF BIOLOGICAL CHEMISTRY 289:25611-25623(2014).
