Recombinant Human DOCK4, GST-tagged

• Cat.No.: DOCK4-12119H
• Product Overview: Recombinant Human DOCK4 protein, fused to GST-tag, was expressed in E.coli and purified by GSH-sepharose.

Specification

• Description: This gene is a member of the dedicator of cytokinesis (DOCK) family and encodes a protein with a DHR-1 (CZH-1) domain, a DHR-2 (CZH-2) domain and an SH3 domain. This membrane-associated, cytoplasmic protein functions as a guanine nucleotide exchange factor and is involved in regulation of adherens junctions between cells. Mutations in this gene have been associated with ovarian, prostate, glioma, and colorectal cancers. Alternatively spliced variants which encode different protein isoforms have been described, but only one has been fully characterized.
• Source: E.coli
• Species: Human
• Tag: GST
• Protein length: C-term-310a.a.
• Storage: The protein is stored in PBS buffer at -20℃. Avoid repeated freezing and thawing cycles.
• Storage Buffer: 1M PBS (58mM Na2HPO4,17mM NaH2PO4, 68mM NaCl, pH8. ) added with 100mM GSH and 1% Triton X-100,15%glycerol.

Gene Information

• Gene Name: DOCK4 dedicator of cytokinesis 4 [ Homo sapiens ]
• Official Symbol: DOCK4
• Synonyms: DOCK4; dedicator of cytokinesis 4; dedicator of cytokinesis protein 4; FLJ34238; KIAA0716; MGC134911; MGC134912
• Gene ID: 9732
• mRNA Refseq: NM_014705
• Protein Refseq: NP_055520
• MIM: 607679
• UniProt ID: Q8N1I0
• Chromosome Location: 7q31.1
• Pathway: Factors involved in megakaryocyte development and platelet production, organism-specific biosystem; Hemostasis, organism-specific biosystem
• Function: GTP binding; GTPase binding; PDZ domain binding; Rac GTPase activator activity; Rac GTPase binding; SH3 domain binding; guanyl-nucleotide exchange factor activity; protein binding; receptor tyrosine kinase binding