DOCK4
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Official Full Name
dedicator of cytokinesis 4 -
Overview
This gene is a member of the dedicator of cytokinesis (DOCK) family and encodes a protein with a DHR-1 (CZH-1) domain, a DHR-2 (CZH-2) domain and an SH3 domain. This membrane-associated, cytoplasmic protein functions as a guanine nucleotide exchange factor and is involved in regulation of adherens junctions between cells. Mutations in this gene have been associated with ovarian, prostate, glioma, and colorectal cancers. Alternatively spliced variants which encode different protein isoforms have been described, but only one has been fully characterized. -
Synonyms
DOCK4;dedicator of cytokinesis 4;dedicator of cytokinesis protein 4;FLJ34238;KIAA0716;MGC134911;MGC134912
Recombinant Proteins
- Human
- Mouse
- E.coli
- Wheat Germ
- Mammalian Cells
- HEK293
- GST
- His
- Avi
- Fc
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| DOCK4-12119H | Recombinant Human DOCK4, GST-tagged | E.coli | Human | GST | C-term-310a.a. | |
| DOCK4-3468H | Recombinant Human DOCK4 protein, His-tagged | E.coli | Human | His | 1838-1971 aa | |
| DOCK4-403H | Recombinant Human DOCK4 Protein, His/GST-tagged | E.coli | Human | GST&His | Met1~Pro300 | |
| DOCK4-2806H | Recombinant Human DOCK4 Protein, GST-tagged | Wheat Germ | Human | GST |
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| DOCK4-4754M | Recombinant Mouse DOCK4 Protein | Mammalian Cells | Mouse | His |
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| DOCK4-2283H | Recombinant Human DOCK4 Protein (Met1-Pro300), N-His tagged | E.coli | Human | His | Met1-Pro300 |
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| DOCK4-2479M | Recombinant Mouse DOCK4 Protein, His (Fc)-Avi-tagged | HEK293 | Mouse | Avi&Fc&His |
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| DOCK4-2479M-B | Recombinant Mouse DOCK4 Protein Pre-coupled Magnetic Beads | HEK293 | Mouse |
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Involved Pathway
DOCK4 involved in several pathways and played different roles in them. We selected most pathways DOCK4 participated on our site, such as Rap signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with DOCK4 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Rap signaling pathway | FGF14,VEGFC,FGFR4,PRKCA,FGF17,FLT4,RAP1B,PLCG1,ID1,FGF21 |
Protein Function
DOCK4 has several biochemical functions, for example, GTPase activator activity,PDZ domain binding,Rac GTPase binding. Some of the functions are cooperated with other proteins, some of the functions could acted by DOCK4 itself. We selected most functions DOCK4 had, and list some proteins which have the same functions with DOCK4. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| PDZ domain binding | FZD2,Apba1,ATP2B3B,SNTB1,GRM7,SLC9A3,SLC26A6,GJA1,CXXC4,ATP2B1A |
| protein binding | SNCG,TUBA1B,BCL2L12,PRDX6,MAPKAP1,SIGIRR,GSK3A,EML1,ZFAND5,GRIN2D |
| GTPase activator activity | ARHGEF15,RANGAP1,TBC1D21,RASAL3,RGS5A,RASA1,ARHGEF6,ARHGEF1,GDI1,ARFGAP3 |
| Rac GTPase binding | SRGAP2,PKN1,PAK2A,PAK2B,HACE1,RCC2,CDKL5,CORO1C,RALBP1,ARHGAP4A |
| receptor tyrosine kinase binding | FLT3LG,TOB1,GNB2L1,PITPNM3,ANGPT4,DNAJA3,PTPN1,NCK1,Flt3l,PTPN2 |
| guanyl-nucleotide exchange factor activity | KALRN,RIC8B,PTGIR,RIC8,ARHGEF1B,VAV3,DOCK11,GDPGP1,TBC1D10A,ARHGEF7A |
| SH3 domain binding | ENKUR,INPPL1B,WIPF3,PLSCR3,MICAL1,BCAR1,SGIP1,INPP5D,ERRFI1,ITGB1BP2 |
Interacting Protein
DOCK4 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with DOCK4 here. Most of them are supplied by our site. Hope this information will be useful for your research of DOCK4.
GRB2;FASLG;HNRNPL;YWHAB
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