Recombinant Human DnaJ (Hsp40) Homolog, Subfamily B, Member 1, GST-tagged

Cat. No. :	DNAJB1-4839H
Description :	DNAJB1 is a member of heat shock proteins (HSPs) which are synthesized in cells in response to heat shock and other metabolic stresses and provide a transient state of thermotolerance. DNAJB1 is localized faintly throughout the cell in non-heat-shocked cells and accumulates in the nuclei and nucleoli in heat-shocked cells. The intracellular localization of DNAJB1 is very similar to that of HSP70. Overexpression of HSP40 reduces aggregate formation and suppresses apoptosis in a neuronal cell model of spinal and bulbar muscular atrophy (inherited neurodegenerative diseases caused by polyglutamine expansion).
Applications :	Western Blot
Molecular Weight :	65 kDa
Expression System :	E.coli
Species :	Human
Form :	Recombinant protein stored in 50 mM Tris-HCl, ph 7.5, 150 mM NaCl, 10 mM glutathione, 0.1 mM EDTA, 0.25 mM DTT, 0.1 mM PMSF, 25 % glycerol.
Purity :	> 90 %
Concentration :	0.2 ug/ul
Sequences :	Full length
Storage :	Store product at -70°C. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
Pathways :	Influenza A; Protein processing in endoplasmic reticulum

Gene Name	DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1 [ Homo sapiens ]
Official Symbol	DNAJB1
Synonyms	DNAJB1; DnaJ (Hsp40) homolog, subfamily B, member 1; Hdj1; Sis1; HSPF1; Hsp40; DNAJ1; HDJ-1; HDJ1; DnaJ protein homolog 1; Heat shock protein 40; Heat shock 40 kDa protein 1; heat shock 40kD protein 1; DnaJ (Hsp40) homolog, subfamily B, member 1; Hsp40 (heat shock protein 40 kD)
Gene ID	3337
mRNA Refseq	NM_006145
Protein Refseq	NP_006136
MIM	604572
UniProt ID	P25685
Chromosome Location	19p13.2
Function	Heat shock protein binding; Unfolded protein binding