Recombinant Human DMPK Protein (M1-P629), His tagged

• Cat.No.: DMPK-0742H
• Product Overview: Recombinant Human 6His-TEV-DMPK(M1-P629 end) Protein was expressed in Insect cell.

Specification

• Species: Human
• Source: Insect Cells
• Tag: His
• Protein Length: M1-P629
• Description: Non-receptor serine/threonine protein kinase which is necessary for the maintenance of skeletal muscle structure and function. May play a role in myocyte differentiation and survival by regulating the integrity of the nuclear envelope and the expression of muscle-specific genes. May also phosphorylate PPP1R12A and inhibit the myosin phosphatase activity to regulate myosin phosphorylation. Also critical to the modulation of cardiac contractility and to the maintenance of proper cardiac conduction activity probably through the regulation of cellular calcium homeostasis. Phosphorylates PLN, a regulator of calcium pumps and may regulate sarcoplasmic reticulum calcium uptake in myocytes. May also phosphorylate FXYD1/PLM which is able to induce chloride currents. May also play a role in synaptic plasticity.
• Form: Liquid
• Endotoxin: < 0.01 EU per μg of the protein
• Purity: 90%
• Stability: Samples are stable for up to twelve months from date of receipt at -20 to -80 centigrade.
• Storage: Store it under sterile conditions at -20 to -80 centigrade. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
• Storage Buffer: Supplied as sterile 50 mM Tris-HCl (pH7.5), 200 mM NaCl, 20% glycerol
• Shipping: It is shipped out with blue ice.

Gene Information

• Gene Name: DMPK dystrophia myotonica-protein kinase [ Homo sapiens (human) ]
• Official Symbol: DMPK
• Synonyms: DMPK; dystrophia myotonica-protein kinase; myotonin-protein kinase; DM; DM protein kinase; DM1; DM1PK; DMK; dystrophia myotonica 1; MDPK; MT PK; myotonic dystrophy associated protein kinase; myotonin protein kinase A; thymopoietin homolog; DM-kinase; DM1 protein kinase; myotonic dystrophy protein kinase; MT-PK
• Gene ID: 1760
• mRNA Refseq: NM_001081563
• Protein Refseq: NP_001075032
• MIM: 605377
• UniProt ID: Q09013