Recombinant Human DLK1, Fc-tagged

• Cat.No.: DLK1-26914TH
• Product Overview: Recombinant fragment corresponding to Signal peptide and extracellular domain of Human DLK fused at the C-terminus to the Fc portion of Human IgG1, 80kDa.

Specification

• Description: This gene encodes a transmembrane protein containing six epidermal growth factor repeats. The protein is involved in the differentiation of several cell types, including adipocytes; it is also thought to be a tumor suppressor. It is one of several imprinted genes located in a region of on chr 14q32. Certain mutations in this imprinted region can cause phenotypes similar to maternal and paternal uniparental disomy of chromosome 14 (UPD14). This gene is expressed from the paternal allele. A polymorphism within this gene has been associated with child and adolescent obesity. The mode of inheritance for this polymorphism is polar overdominance; this non-Mendelian inheritance pattern was first described in sheep with the callipyge phenotype, which is characterized by muscle hypertrophy and decreased fat mass.
• Protein length: 303 amino acids
• Conjugation: Fc
• Molecular Weight: 80.000kDa
• Source: HEK 293 cells
• Tissue specificity: Found within the stromal cells in close contact to the vascular structure of placental villi, yolk sac, fetal liver, adrenal cortex and pancreas and in the beta cells of the islets of Langerhans in the adult pancreas. Found also in some forms of neuroendo
• Biological activity: Inhibits adipogenesis of 3T3L1 cells.
• Form: Liquid
• Purity: >90% by SDS-PAGE
• Storage buffer: Preservative: NoneConstituents: PBS
• Storage: Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
• Sequence Similarities: Contains 6 EGF-like domains.

Gene Information

• Gene Name: DLK1 delta-like 1 homolog (Drosophila) [ Homo sapiens ]
• Official Symbol: DLK1
• Synonyms: DLK1; delta-like 1 homolog (Drosophila); delta like homolog (Drosophila); protein delta homolog 1; FA1; pG2; Pref 1; ZOG
• Gene ID: 8788
• mRNA Refseq: NM_003836
• Protein Refseq: NP_003827
• MIM: 176290
• Uniprot ID: P80370
• Chromosome Location: 14q32
• Pathway: Adipogenesis, organism-specific biosystem; FOXA2 and FOXA3 transcription factor networks, organism-specific biosystem; Notch signaling pathway, organism-specific biosystem
• Function: molecular_function