Recombinant Human DLC1, His-tagged
| Cat.No. : | DLC1-12016H |
| Product Overview : | Recombinant Human DLC1 protein, fused to His-tag, was expressed in E.coli and purified by Ni-sepharose. |
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| Description : | This gene encodes a GTPase-activating protein (GAP) that is a member of the rhoGAP family of proteins which play a role in the regulation of small GTP-binding proteins. GAP family proteins participate in signaling pathways that regulate cell processes involved in cytoskeletal changes. This gene functions as a tumor suppressor gene in a number of common cancers, including prostate, lung, colorectal, and breast cancers. Multiple transcript variants due to alternative promoters and alternative splicing have been found for this gene. |
| Source : | E.coli |
| Species : | Human |
| Tag : | His |
| Protein length : | 1179-1528a.a. |
| Storage : | The protein is stored in PBS buffer at -20℃. Avoid repeated freezing and thawing cycles. |
| Storage Buffer : | 1M PBS (58mM Na2HPO4,17mM NaH2PO4, 68mM NaCl, pH8. ) added with 300mM Imidazole and 0.7% Sarcosyl, 15%glycerol. |
| Gene Name | DLC1 deleted in liver cancer 1 [ Homo sapiens ] |
| Official Symbol | DLC1 |
| Synonyms | DLC1; deleted in liver cancer 1; rho GTPase-activating protein 7; ARHGAP7; DLC 1; HP; p122 RhoGAP; StAR related lipid transfer (START) domain containing 12; STARD12; Rho-GTPase-activating protein 7; deleted in liver cancer 1 protein; START domain-containing protein 12; deleted in liver cancer 1 variant 2; rho-type GTPase-activating protein 7; StAR-related lipid transfer (START) domain containing 12; p122-RhoGAP; FLJ21120; |
| Gene ID | 10395 |
| mRNA Refseq | NM_001164271 |
| Protein Refseq | NP_001157743 |
| MIM | 604258 |
| UniProt ID | Q96QB1 |
| Chromosome Location | 8p22 |
| Pathway | Regulation of RhoA activity, organism-specific biosystem; Rho GTPase cycle, organism-specific biosystem; Signal Transduction, organism-specific biosystem; Signaling by Rho GTPases, organism-specific biosystem; |
| Function | GTPase activator activity; NOT Rac GTPase activator activity; Rho GTPase activator activity; Rho GTPase activator activity; SH2 domain binding; phospholipase binding; protein binding; vinculin binding; |
Not For Human Consumption!
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