DLC1
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Official Full Name
deleted in liver cancer 1 -
Overview
DLC1 is a protein which in humans is encoded by the DLC1 gene. This gene is deleted in the primary tumor of hepatocellular carcinoma. It is suggested that this gene is a candidate tumor suppressor gene for human liver cancer, as well as for prostate, lung, colorectal and breast cancers. -
Synonyms
DLC1;deleted in liver cancer 1;rho GTPase-activating protein 7;ARHGAP7;DLC 1;HP;p122 RhoGAP;StAR related lipid transfer (START) domain containing 12;STARD12;Rho-GTPase-activating protein 7;deleted in liver cancer 1 protein;START domain-containing protein 12;deleted in liver cancer 1 variant 2;rho-type GTPase-activating protein 7;StAR-related lipid transfer (START) domain containing 12;p122-RhoGAP;FLJ21120
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| DLC1-12016H | Recombinant Human DLC1, His-tagged | E.coli | Human | His | 1179-1528a.a. | |
| DLC1-5133H | Recombinant Human DLC1, GST-tagged | E.coli | Human | GST | 899-996 a.a. |
|
| DLC1-6913HCL | Recombinant Human DLC1 293 Cell Lysate | HEK293 | Human | Non |
|
Involved Pathway
DLC1 involved in several pathways and played different roles in them. We selected most pathways DLC1 participated on our site, such as Regulation of RhoA activity,Rho GTPase cycle,Signal Transduction, which may be useful for your reference. Also, other proteins which involved in the same pathway with DLC1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Signaling by Rho GTPases | NOXO1A,KIF14,ARHGAP33,ARHGAP26,FGD4A,RHOU,ARHGAP44,ARHGEF18A,NF2A,ARHGAP24 |
| Rho GTPase cycle | ARHGEF18,ARHGAP6,ARHGAP24,ABR,ARAP1,ARHGAP10,ARHGAP20,ARHGEF17,GMIP,ARHGAP29B |
| Signal Transduction | RDH14,KEL,GDI2,OXGR1A.3,RGS1,RDH13,WDR19,RLN3A,EVC,BBS13 |
| Regulation of RhoA activity | FARP1,ARHGEF28,ARHGEF10,ECT2,PLEKHG6,ABR,DEF6,NET1,MYO9B,ARHGEF3 |
Protein Function
DLC1 has several biochemical functions, for example, GTPase activator activity,NOT GTPase activator activity,SH2 domain binding. Some of the functions are cooperated with other proteins, some of the functions could acted by DLC1 itself. We selected most functions DLC1 had, and list some proteins which have the same functions with DLC1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| GTPase activator activity | ARHGAP31,CDC42EP2,AXIN2,TBC1D17,TBC1D19,SRGAP3,RABGAP1,RGS9B,ASAP2A,STARD13 |
| lipid binding | PITPNM3,CYTH1,ZFYVE26,GLTP,PITPNA,FABP6,PACSIN1B,ACBD5,SEC14L4,INPP4B |
| SH2 domain binding | SIT1,GNB2L1,LILRB1,INPPL1,ARHGAP5,SYP,CRK,SKAP1,PTK2,AFAP1L2 |
| protein binding | POC1B,TTK,AMMECR1,DYNC1I1,GAB3,IGF2R,RCBTB2,MARCH10,AES,NPHP4 |
| NOT GTPase activator activity | ARAP3,ELMOD3 |
Interacting Protein
DLC1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with DLC1 here. Most of them are supplied by our site. Hope this information will be useful for your research of DLC1.
RASA1;TNS3;TMEM129;ACOT7;FBP2;CDC14B;CTSV;ZNF189;TGFB1;PFKM;PKM;XPA;TMOD1;HSD17B3
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References
- Jung, S; Kim, S; et al. DNA Methylation in Multiple Myeloma Is Weakly Associated with Gene Transcription. PLOS ONE 7:-(2012).
- Hutajulu, SH; Indrasari, SR; et al. Epigenetic markers for early detection of nasopharyngeal carcinoma in a high risk population. MOLECULAR CANCER 10:-(2011).
