Recombinant Human DIABLO, His-tagged

• Cat.No.: DIABLO-30929TH
• Product Overview: Recombinant full length Human Smac / Diablo with a 6x His and a proprietary tag; 485 amino acids including tag, Predicted MWt 56.1 kDa .

Specification

• Description: This gene encodes an inhibitor of apoptosis protein (IAP)-binding protein. The encoded mitochondrial protein enters the cytosol when cells undergo apoptosis, and it moderates the caspase inhibition of IAPs. Multiple polyadenylation sites have been found for this gene. Four alternatively spliced transcript variants have been described for this gene, with two of them encoding different isoforms and the other two probably not encoding a protein.
• Protein length: 239 amino acids
• Conjugation: HIS
• Molecular Weight: 56.100kDa inclusive of tags
• Source: E. coli
• Tissue specificity: Ubiquitously expressed with highest expression in testis. Expression is also high in heart, liver, kidney, spleen, prostate and ovary. Low in brain, lung, thymus and peripheral blood leukocytes.
• Form: Liquid
• Purity: >90% by SDS-PAGE
• Storage buffer: pH: 7.40Constituent:99% PBS
• Storage: Shipped on dry ice. Upon delivery aliquot and store at -80oC. Avoid freeze / thaw cycles.

Gene Information

• Gene Name: DIABLO diablo, IAP-binding mitochondrial protein [ Homo sapiens ]
• Official Symbol: DIABLO
• Synonyms: DIABLO; diablo, IAP-binding mitochondrial protein; diablo homolog, mitochondrial; DFNA64; DIABLO S; FLJ10537; FLJ25049; second mitochondria derived activator of caspase; SMAC
• Gene ID: 56616
• mRNA Refseq: NM_019887
• Protein Refseq: NP_063940
• MIM: 605219
• Uniprot ID: Q9NR28
• Chromosome Location: 12q24.31
• Pathway: Apoptosis, organism-specific biosystem; Apoptosis, organism-specific biosystem; Apoptotic factor-mediated response, organism-specific biosystem; Caspase cascade in apoptosis, organism-specific biosystem; Intrinsic Pathway for Apoptosis, organism-specific biosystem
• Function: protein binding