DIABLO
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Official Full Name
diablo, IAP-binding mitochondrial protein -
Overview
This gene encodes an inhibitor of apoptosis protein (IAP)-binding protein. The encoded mitochondrial protein enters the cytosol when cells undergo apoptosis, and allows activation of caspases by binding to inhibitor of apoptosis proteins. Overexpression of the encoded protein sensitizes tumor cells to apoptosis. A mutation in this gene is associated with young-adult onset of nonsyndromic deafness-64. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, May 2013] -
Synonyms
DIABLO;diablo, IAP-binding mitochondrial protein;SMAC;DFNA64;diablo homolog, mitochondrial;direct IAP-binding protein with low pI;second mitochondria-derived activator of caspase
Recombinant Proteins
- Human
- Mouse
- E.coli
- Yeast
- Wheat Germ
- Mammalian Cell
- HEK293
- In Vitro Cell Free System
- HEK293T
- His
- GST
- His&GST
- Non
- T7
- His&Fc&Avi
- Myc&DDK
Involved Pathway
DIABLO involved in several pathways and played different roles in them. We selected most pathways DIABLO participated on our site, such as Apoptosis,Apoptosis Modulation and Signaling,Apoptotic factor-mediated response, which may be useful for your reference. Also, other proteins which involved in the same pathway with DIABLO were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Apoptosis | HMGB2,PRKAR2A,AKT3A,PRKAR1A,IL3RA,MYD88,CLSPN,TNFRSFA,CASP6L2,XIAP |
| SMAC binds to IAPs | DIABLOB,DIABLOA |
| Programmed Cell Death | SATB1,BAXB,DSG1,Gzmg,PANK1A,DBNL,RIPK3,BCAP31,GAS2,CASP6L2 |
| Apoptosis Modulation and Signaling | BCL2L10,BIK,CAPNS1,HRK,CRADD,HN1,PTPN13,BOK,SEPT4,BLK |
| Intrinsic Pathway for Apoptosis | GZMF,DIABLOB,GZME,Gzmg,BAXB,NMT1,DIABLOA,GZMC |
| Caspase cascade in apoptosis | PARP1,CRADD,SATB1,LMNB1,GAS2,ACTA1,TOP1,CASP2,TFAP2A,NUMA1 |
| Apoptotic factor-mediated response | DIABLOA,DIABLOB |
| Release of apoptotic factors from the mitochondria | DIABLOA,DIABLOB |
Protein Function
DIABLO has several biochemical functions, for example, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by DIABLO itself. We selected most functions DIABLO had, and list some proteins which have the same functions with DIABLO. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein binding | SIAH1,LIMD1,TTN,LIMD2,GPR158,GSS,HNRNPM,THEG,DNAJC28,BCAR1 |
Interacting Protein
DIABLO has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with DIABLO here. Most of them are supplied by our site. Hope this information will be useful for your research of DIABLO.
XIAP;BIRC2;BIRC7
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References
- Smolewski, P; Robak, P; et al. Pro-apoptotic effect of an anti-CD37 scFv-Fc fusion protein, in combination with the anti-CD20 antibody, ofatumumab, on tumour cells from B-cell malignancies. EUROPEAN JOURNAL OF CANCER 50:2677-2684(2014).
- Hernandez-Jimenez, M; Sacristan, S; et al. Apoptosis-related proteins are potential markers of neonatal hypoxic-ischemic encephalopathy (HIE) injury. NEUROSCIENCE LETTERS 558:143-148(2014).
