Recombinant Human DHODH, MYC/DDK-tagged

• Cat.No.: DHODH-4839H
• Product Overview: Recombinant Human DHODH fused with C-terminal MYC/DDK, was expressed in Human 293HEK cells.

Specification

• Species: Human
• Source: HEK293
• Tag: DDK&Myc
• Description: The protein encoded by this gene catalyzes the fourth enzymatic step, the ubiquinone-mediated oxidation of dihydroorotate to orotate, in de novo pyrimidine biosynthesis. This protein is a mitochondrial protein located on the outer surface of the inner mitochondrial membrane.
• Molecular Mass: 41.6 kDa
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining
• Storage: Store at -80C. Avoid repeated freeze-thaw cycles. Stable for at least 3 months from receipt of products under proper storage and handling conditions.
• Concentration: >50 ug/mL as determined by microplate BCA method
• Storage Buffer: 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol.

Gene Information

• Gene Name: DHODH dihydroorotate dehydrogenase (quinone) [ Homo sapiens (human) ]
• Official Symbol: DHODH
• Synonyms: DHODH; URA1; POADS; DHOdehase; dihydroorotate dehydrogenase (quinone); dihydroorotate dehydrogenase (quinone), mitochondrial; dihydroorotate oxidase; human complement of yeast URA1; NP_001352.2; EC 1.3.5.2
• Gene ID: 1723
• mRNA Refseq: NM_001361
• Protein Refseq: NP_001352
• MIM: 126064
• UniProt ID: Q02127
• Chromosome Location: 16q22
• Pathway: Metabolism; Pyrimidine biosynthesis; Pyrimidine metabolism; Uridine monophosphate biosynthesis, glutamine (+ PRPP) => UMP
• Function: FMN binding; dihydroorotate dehydrogenase activity; dihydroorotate oxidase activity