DHODH
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Official Full Name
dihydroorotate dehydrogenase (quinone) -
Overview
The protein encoded by this gene catalyzes the fourth enzymatic step, the ubiquinone-mediated oxidation of dihydroorotate to orotate, in de novo pyrimidine biosynthesis. This protein is a mitochondrial protein located on the outer surface of the inner mitochondrial membrane. -
Synonyms
DHODH;dihydroorotate dehydrogenase (quinone);dihydroorotate dehydrogenase;dihydroorotate dehydrogenase (quinone), mitochondrial;dihydroorotate oxidase;human complement of yeast URA1;URA1;POADS;DHOdehase
Recombinant Proteins
- Human
- Rat
- Mouse
- Chicken
- Zebrafish
- Pongo Abelii
- Bovine
- Mus musculus
- E.coli
- Insect Cells
- Mammalian Cells
- Wheat Germ
- HEK293
- In Vitro Cell Free System
- His
- GST
- Myc&DDK
- Non
- His&Fc&Avi
- Flag
Involved Pathway
DHODH involved in several pathways and played different roles in them. We selected most pathways DHODH participated on our site, such as Metabolic pathways,Metabolism,Metabolism of nucleotides, which may be useful for your reference. Also, other proteins which involved in the same pathway with DHODH were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Metabolism | CYP2D6,GLYATL2,UGT1B7,FABP1B.1,ATP5S,SLC25A32B,CYP2W1,CYP2K16,PDK4,ADAL |
| Pyrimidine biosynthesis | DUT |
| Metabolism of nucleotides | DGUOK,GRX2,ADSS,DUT,PNP5B,ADSL,NUDT5,NUDT18,NUDT1,PAICS |
| Pyrimidine metabolism | POLR2B,UCK2A,NME7,NT5C2A,POLR2GL,ENTPD3,NME2A,UCKL1,NT5C3L,POLR3GLB |
| Metabolic pathways | CHIA.2,ACADS,CHPF2,UGCG,DHCR7,PI4KB,UGT1A3,HYKK,DGKE,MTMR8 |
Protein Function
DHODH has several biochemical functions, for example, FMN binding,dihydroorotate dehydrogenase activity,drug binding. Some of the functions are cooperated with other proteins, some of the functions could acted by DHODH itself. We selected most functions DHODH had, and list some proteins which have the same functions with DHODH. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| FMN binding | NDOR1,NOS3,TYW1,NOS2B,TYW1B,NOS2,CREG1,HAO1,NOS1,MTRR |
| ubiquinone binding | SDHDA,SDHD,ETFDH,SDHDB,SDHB |
| drug binding | CHRNA3,TLR8,GRIK1,PYGL,SRP54A,TYMS,HTR2C,SETD6,HTR2B,SRP54 |
Interacting Protein
DHODH has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with DHODH here. Most of them are supplied by our site. Hope this information will be useful for your research of DHODH.
MT2A;TMED10
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References
- Schaefer, CM; Schafer, MKH; et al. Region-Specific Distribution of Dihydroorotate Dehydrogenase in the Rat Central Nervous System Points to Pyrimidine De Novo Synthesis in Neurons. NUCLEOSIDES NUCLEOTIDES & NUCLEIC ACIDS 29:476-481(2010).
- Thomson, TA; Spinella-Jaegle, S; et al. In vitro and In vivo inhibition of immunoglobulin secretion by the immunosuppressive compound HR325 is reversed by exogenous uridine. SCANDINAVIAN JOURNAL OF IMMUNOLOGY 56:35-42(2002).
