Recombinant Human DGUOK Protein, His-tagged

• Cat.No.: DGUOK-772H
• Product Overview: Recombinant Human DGUOK, transcript variant 2, fused with His tag at N-terminal was expressed in E. coli.

Specification

• Species: Human
• Source: E.coli
• Tag: His
• Description: In mammalian cells, the phosphorylation of purine deoxyribonucleosides is mediated predominantly by two deoxyribonucleoside kinases, cytosolic deoxycytidine kinase and mitochondrial deoxyguanosine kinase. The protein encoded by this gene is responsible for phosphorylation of purine deoxyribonucleosides in the mitochondrial matrix. In addition, this protein phosphorylates several purine deoxyribonucleoside analogs used in the treatment of lymphoproliferative disorders, and this phosphorylation is critical for the effectiveness of the analogs. Alternative splice variants encoding different protein isoforms have been described for this gene.
• Form: 50mM Tris, 8M Urea, pH8.0
• Molecular Mass: 17.3 kDa
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining
• Concentration: >50 ug/mL as determined by microplate BCA method

Gene Information

• Gene Name: DGUOK deoxyguanosine kinase [ Homo sapiens ]
• Official Symbol: DGUOK
• Synonyms: DGUOK; deoxyguanosine kinase; deoxyguanosine kinase, mitochondrial; dGK; MTDPS3
• Gene ID: 1716
• mRNA Refseq: NM_080916
• Protein Refseq: NP_550438
• MIM: 601465
• UniProt ID: Q16854