Recombinant Human DCAF6, His-tagged

• Cat.No.: DCAF6-27575TH
• Product Overview: Recombinant fragment, corresponding to amino acids 536-860 of Human NRIP with N terminal His tag; 325 amino acids, 74kDa.

Specification

• Species: Human
• Source: E.coli
• Tag: His
• Protein Length: 536-860 a.a.
• Description: WD-repeat proteins are a large family of eukaryotic proteins coordinating multi-protein complex assemblies. Their role has been implicated in multiple cellular processes including signal transduction, transcriptional regulation, cell cycle control and apoptosis. NRIP is a novel 860a.a nuclear protein consisting of seven conserved WD40 domains and one NLS motif. It binds to androgen and glucocorticoid receptors and up-regulates their transcriptional activity, thereby functioning as a nuclear receptor co-activator. Role of NRIP has been implicated in cell growth and also in cervical and prostrate cancer, thus indicating a potential therapeutic intervention. Northern Blot analysis detects a high expression of NRIP in skeletal muscle and testis and low expression in heart, prostrate and adrenal gland.
• Conjugation: HIS
• Form: Lyophilised:Reconstitute with 68 μl aqua dest.
• Storage buffer: Preservative: NoneConstituents: 0.5% Trehalose, 6M Urea, 100mM Sodium phosphate, 10mM Sodium chloride, pH 4.5
• Storage: Shipped at 4°C. Upon delivery aliquot and store at -80oC. Avoid freeze / thaw cycles.
• Sequences of amino acids: ETKAPEESSEDVTKYQEGVSAENPVENHINITQSDKFTAK PLDSNSGERNDLNLDRSCGVPEESASSEKAKEPETSDQ TSTESATNENNTNPEPQFQTEATGPSAHEETSTRDSAL QDTDDSDDDPVLIPGARYRAGPGDRRSAVARIQEFFRRRK ERKEMEELDTLNIRRPLVKMVYKGHRNSRTMIKEANFW GANFVMSGSDCGHIFIWDRHTAEHLMLLEADNHVVNCL QPHPFDPILASSGIDYDIKIWSPLEESRIFNRKLADEVIT RNELMLEETRNTITVPASFMLRMLASLNHIRADRLEGD RSEGSGQENENEDEE

Gene Information

• Gene Name: DCAF6 DDB1 and CUL4 associated factor 6 [ Homo sapiens ]
• Official Symbol: DCAF6
• Synonyms: DCAF6; DDB1 and CUL4 associated factor 6; IQ motif and WD repeats 1 , IQWD1; DDB1- and CUL4-associated factor 6; PC326
• Gene ID: 55827
• mRNA Refseq: NM_018442
• Protein Refseq: NP_060912
• MIM: 610494
• Uniprot ID: Q58WW2
• Chromosome Location: 1q23.3
• Function: ligand-dependent nuclear receptor transcription coactivator activity