Recombinant Human DAXX Protein, Myc/DDK-tagged, C13 and N15-labeled

• Cat.No.: DAXX-4829H
• Product Overview: DAXX MS Standard C13 and N15-labeled recombinant protein (NP_001135441) with a C-terminal MYC/DDK tag, was expressed in HEK293 cells.

Specification

• Description: This gene encodes a multifunctional protein that resides in multiple locations in the nucleus and in the cytoplasm. It interacts with a wide variety of proteins, such as apoptosis antigen Fas, centromere protein C, and transcription factor erythroblastosis virus E26 oncogene homolog 1. In the nucleus, the encoded protein functions as a potent transcription repressor that binds to sumoylated transcription factors. Its repression can be relieved by the sequestration of this protein into promyelocytic leukemia nuclear bodies or nucleoli. This protein also associates with centromeres in G2 phase. In the cytoplasm, the encoded protein may function to regulate apoptosis. The subcellular localization and function of this protein are modulated by post-translational modifications, including sumoylation, phosphorylation and polyubiquitination. Alternative splicing results in multiple transcript variants.
• Source: HEK293
• Species: Human
• Tag: Myc&DDK
• Molecular Mass: 81.4 kDa
• AA Sequence: MATANSIIVLDDDDEDEAAAQPGPS HPLPNAASPGAEAPSSSEPHGARGS SSSGGKKCYKLENEKLFEEFLELCK MQTADHPEVVPFLYNRQQRAHSLFL ASAEFCNILSRVLSRARSRPAKLYV YINELCTVLKAHSAKKKLNLAPAAT TSNEPSGNNPPTHLSLDPTNAENTA SQSPRTRGSRRQIQRLEQLLALYVA EIRRLQEKELDLSELDDPDSAYLQE ARLKRKLIRLFGRLCELKDCSSLTG RVIEQRIPYRGTRYPEVNRRIERLI NKPGPDTFPDYGDVLRAVEKAAARH SLGLPRQQLQLMAQDAFRDVGIRLQ ERRHLDLIYNFGCHLTDDYRPGVDP ALSDPVLARRLRENRSLAMSRLDEV ISKYAMLQDKSEEGERKKRRARLQG TSSHSADTPEASLDSGEGPSGMASQ GCPSASRAETDDEDDEESDEEEEEE EEEEEEEATDSEEEEDLEQMQEGQE DDEEEDEEEEAAAGKDGDKSPMSSL QISNEKNLEPGKQISRSSGEQQNKG RIVSPSLLSEEPLAPSSIDAESNGE QPEELTLEEESPVSQLFELEIEALP LDTPSSVETDISSSRKQSEEPFTTV LENGAGMVSSTSFNGGVSPHNWGDS GPPCKKSRKEKKQTGSGPLGNSYVE RQRSVHEKNGKKICTLPSPPSPLAS LAPVADSSTRVDSPSHGLVTSSLCI PSPARLSQTPHSQPPRPGTCKTSVA TQCDPEEIIVLSDSDTRTRPLEQKL ISEEDLAANDILDYKDDDDKV
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining
• Stability: Stable for 3 months from receipt of products under proper storage and handling conditions.
• Storage: Store at -80 centigrade. Avoid repeated freeze-thaw cycles.
• Concentration: 50 μg/mL as determined by BCA
• Storage Buffer: 100 mM glycine, 25 mM Tris-HCl, pH 7.3.

Gene Information

• Gene Name: DAXX death-domain associated protein [ Homo sapiens (human) ]
• Official Symbol: DAXX
• Synonyms: DAXX; death-domain associated protein; death associated protein 6; death domain-associated protein 6; DAP6; Fas-binding protein; CENP-C binding protein; ETS1-associated protein 1; death-associated protein 6; fas death domain-associated protein; EAP1; BING2; MGC126245; MGC126246
• Gene ID: 1616
• mRNA Refseq: NM_001141969
• Protein Refseq: NP_001135441
• MIM: 603186
• UniProt ID: Q9UER7

Reviews

01/29/2021

Its ability to provide accurate and reliable results in this particular application makes it a preferred choice for researchers studying antigen-antibody interactions and immune responses.

09/27/2019

The DAXX protein's sensitivity and specificity ensure precise measurements, contributing to the overall success of ELISA experiments.

10/26/2018

the DAXX protein has proven to be invaluable in protein electron microscopy structure analysis.

Q&As

How does DAXX protein interact with other cellular proteins in the context of clinical applications?

DAXX protein interacts with a wide range of cellular proteins, including transcription factors, histones, and chromatin remodeling complexes, which has implications for its clinical relevance in various cellular processes.

What are the potential therapeutic implications of targeting DAXX protein?

Targeting DAXX protein may have therapeutic implications in cancer treatment, as well as in aging-related diseases and neurodegenerative disorders, by modulating its functions and interactions with other cellular proteins.

Are there any clinical implications of DAXX protein in aging-related diseases?

Studies have suggested that DAXX protein may have implications in aging-related diseases, particularly in relation to telomere dysfunction and cellular senescence.

How does DAXX protein contribute to the development of neurodegenerative diseases?

DAXX protein has been implicated in neurodegenerative diseases through its involvement in cellular stress responses and protein aggregation, which are hallmarks of diseases such as Alzheimer's and Parkinson's.

Can DAXX protein be used as a therapeutic target for cancer treatment?

DAXX protein has been identified as a potential therapeutic target for cancer treatment due to its involvement in regulating the activity of key oncogenes and tumor suppressor genes.