Recombinant Human DAXX Protein, His&GST-tagged

• Cat.No.: DAXX-1315H
• Product Overview: Recombinant Human DAXX Protein (Met1-Pro160) with N-His&GST tag was expressed in E. coli.

Specification

• Description: This gene encodes a multifunctional protein that resides in multiple locations in the nucleus and in the cytoplasm. It interacts with a wide variety of proteins, such as apoptosis antigen Fas, centromere protein C, and transcription factor erythroblastosis virus E26 oncogene homolog 1. In the nucleus, the encoded protein functions as a potent transcription repressor that binds to sumoylated transcription factors. Its repression can be relieved by the sequestration of this protein into promyelocytic leukemia nuclear bodies or nucleoli. This protein also associates with centromeres in G2 phase. In the cytoplasm, the encoded protein may function to regulate apoptosis. The subcellular localization and function of this protein are modulated by post-translational modifications, including sumoylation, phosphorylation and polyubiquitination. Alternative splicing results in multiple transcript variants.
• Source: E. coli
• Species: Human
• Tag: His&GST
• Form: Freeze-dried powder
• Molecular Mass: Predicted Molecular Mass: 47.2 kDa
  Accurate Molecular Mass: 51 kDa
• Protein length: Met1-Pro160
• Purity: > 95%
• Applications: Positive Control; Immunogen; SDS-PAGE; WB.
• Stability: The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37 centigrade for 48h, and no obvious degradation and precipitation were observed. The loss rate is less than 5% within the expiration date under appropriate storage condition.
• Storage: Avoid repeated freeze/thaw cycles. Store at 2-8 centigrade for one month. Aliquot and store at -80 centigrade for 12 months.
• Storage Buffer: 100mM NaHCO3, 500mM NaCl, pH8.3, containing 1mM EDTA, 1mM DTT, 0.01% SKL, 5% Trehalose and Proclin300.
• Reconstitution: Reconstitute in 100mM NaHCO3, 500mM NaCl (pH8.3) to a concentration of 0.1-1.0 mg/mL. Do not vortex.

Gene Information

• Gene Name: DAXX death domain associated protein [ Homo sapiens (human) ]
• Official Symbol: DAXX
• Synonyms: DAXX; death domain associated protein; DAP6; EAP1; BING2; SMIM40; death domain-associated protein 6; CENP-C binding protein; ETS1-associated protein 1; Fas-binding protein; death-associated protein 6; fas death domain-associated protein
• Gene ID: 1616
• mRNA Refseq: NM_001350
• Protein Refseq: NP_001341
• MIM: 603186
• UniProt ID: Q9UER7

Reviews

01/29/2021

Its ability to provide accurate and reliable results in this particular application makes it a preferred choice for researchers studying antigen-antibody interactions and immune responses.

09/27/2019

The DAXX protein's sensitivity and specificity ensure precise measurements, contributing to the overall success of ELISA experiments.

10/26/2018

the DAXX protein has proven to be invaluable in protein electron microscopy structure analysis.

Q&As

How does DAXX protein interact with other cellular proteins in the context of clinical applications?

DAXX protein interacts with a wide range of cellular proteins, including transcription factors, histones, and chromatin remodeling complexes, which has implications for its clinical relevance in various cellular processes.

What are the potential therapeutic implications of targeting DAXX protein?

Targeting DAXX protein may have therapeutic implications in cancer treatment, as well as in aging-related diseases and neurodegenerative disorders, by modulating its functions and interactions with other cellular proteins.

Are there any clinical implications of DAXX protein in aging-related diseases?

Studies have suggested that DAXX protein may have implications in aging-related diseases, particularly in relation to telomere dysfunction and cellular senescence.

How does DAXX protein contribute to the development of neurodegenerative diseases?

DAXX protein has been implicated in neurodegenerative diseases through its involvement in cellular stress responses and protein aggregation, which are hallmarks of diseases such as Alzheimer's and Parkinson's.

Can DAXX protein be used as a therapeutic target for cancer treatment?

DAXX protein has been identified as a potential therapeutic target for cancer treatment due to its involvement in regulating the activity of key oncogenes and tumor suppressor genes.