Recombinant Human CYP3A5 protein, MYC/DDK-tagged

• Cat.No.: CYP3A5-12H
• Product Overview: Recombinant Human CYP3A5 fused with MYC/DDK tag at C-terminal was expressed in HEK293.

Specification

• Species: Human
• Source: HEK293
• Tag: DDK&Myc
• Description: This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. The encoded protein metabolizes drugs as well as the steroid hormones testosterone and progesterone. This gene is part of a cluster of cytochrome P450 genes on chromosome 7q21.1. Two pseudogenes of this gene have been identified within this cluster on chromosome 7. Expression of this gene is widely variable among populations, and a single nucleotide polymorphism that affects transcript splicing has been associated with susceptibility to hypertensions. Alternative splicing results in multiple transcript variants.
• Form: 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol.
• Molecular Mass: 56.9 kDa
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining
• Concentration: >50 ug/mL as determined by microplate BCA method

Gene Information

• Gene Name: CYP3A5 cytochrome P450, family 3, subfamily A, polypeptide 5 [ Homo sapiens ]
• Official Symbol: CYP3A5
• Synonyms: CYP3A5; cytochrome P450, family 3, subfamily A, polypeptide 5; cytochrome P450, subfamily IIIA (niphedipine oxidase), polypeptide 5; cytochrome P450 3A5; CP35; P450PCN3; PCN3; cytochrome P-450; niphedipine oxidase; cytochrome P450 HLp2; cytochrome P450-PCN3; microsomal monooxygenase; xenobiotic monooxygenase; aryl hydrocarbon hydroxylase; flavoprotein-linked monooxygenase; CYPIIIA5; FLJ31317; DKFZp686L16231
• Gene ID: 1577
• mRNA Refseq: NM_000777
• Protein Refseq: NP_000768
• MIM: 605325
• UniProt ID: P20815
• Chromosome Location: 7q21.1
• Pathway: Biological oxidations, organism-specific biosystem; Cytochrome P450 - arranged by substrate type, organism-specific biosystem; Drug metabolism - cytochrome P450, organism-specific biosystem; Drug metabolism - cytochrome P450, conserved biosystem; Drug metabolism - other enzymes, organism-specific biosystem; Drug metabolism - other enzymes, conserved biosystem; Irinotecan Pathway, organism-specific biosystem
• Function: aromatase activity; electron carrier activity; heme binding; metal ion binding; monooxygenase activity; oxidoreductase activity; oxygen binding