CYP3A5
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Official Full Name
cytochrome P450, family 3, subfamily A, polypeptide 5 -
Overview
This gene,CYP3A5, encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and its expression is induced by glucocorticoids and some pharmacological agents. The enzyme metabolizes drugs such as cyclosporine as well as the steroid hormones testosterone, progesterone and androstenedione. This gene is part of a cluster of cytochrome P450 genes on chromosome 7q21.1. This cluster includes a pseudogene, CYP3A5P1, which is very similar to CYP3A5. This similarity has caused some difficulty in determining whether cloned sequences represent the gene or the pseudogene. Multiple alternatively spliced transcript variants have been identified for this gene. -
Synonyms
CYP3A5;cytochrome P450, family 3, subfamily A, polypeptide 5;cytochrome P450, subfamily IIIA (niphedipine oxidase), polypeptide 5;cytochrome P450 3A5;CP35;P450PCN3;PCN3;cytochrome P-450;niphedipine oxidase;cytochrome P450 HLp2;cytochrome P450-PC
Recombinant Proteins
- Human
- Rhesus macaque
- Cynomolgus
- E.coli
- Insect Cell
- Mammalian Cell
- HEK293
- Wheat Germ
- In Vitro Cell Free System
- HEK293T
- GST
- Non
- His
- Myc&DDK
- His&Fc&Avi
Involved Pathway
CYP3A5 involved in several pathways and played different roles in them. We selected most pathways CYP3A5 participated on our site, such as Aflatoxin activation and detoxification,Biological oxidations,Chemical carcinogenesis, which may be useful for your reference. Also, other proteins which involved in the same pathway with CYP3A5 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Cytochrome P450 - arranged by substrate type | CYP11B2,CYP2K17,CYP2C19,CYP4F12,CYP1B1,CYP11B1,CYP3A7-CYP3AP1,CYP11A1,FDX1,CYP2K8 |
| Drug metabolism - cytochrome P450 | CYP2C8,ADH7,CYP2E1,CYP2D6,ADH2-1,CYP2C9,ADH5,ADH1C,ADH1A,CYP2C19 |
| Chemical carcinogenesis | UGT1A9,SULT2A1,Nat3,CYP2A13,GSTT2,CYP2C37,UGT1A7C,AKR1C2,ADH2-1,ADH4 |
| Aflatoxin activation and detoxification | CYP3C1,GGT6,DPEP1,ACY3,FAM84B,CYP2Y3,GGTLC1,CYP3C4,CYP1A2,CYP3A4 |
| Biological oxidations | FDX1L,CYP2A7,CYP51A1,CYP4F12,AHCY,ADH8B,SULT1C2,UGT1B1,CYP2AD2,CYP24A1 |
| Metabolism | FABP12,COX11,CYP2AD6,APOC2,MED22,PROZA,COX10,ACSF3,COQ6,LYPLA1 |
| Metabolic pathways | POLE4,MTHFR,PPCS,CS,PKLR,UGP2B,SPHK1,PIGU,ENPP3,ATP5G1 |
Protein Function
CYP3A5 has several biochemical functions, for example, aromatase activity,heme binding,iron ion binding. Some of the functions are cooperated with other proteins, some of the functions could acted by CYP3A5 itself. We selected most functions CYP3A5 had, and list some proteins which have the same functions with CYP3A5. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| oxidoreductase activity | TDH,CYP2X7,GPD1B,CYP11C1,CYP2AD2,CYP1A,C10orf33,CYP2A12,HIBADHA,CYP4V7 |
| oxygen binding | CYP2J6,CYP19A1,HBB-Y,CYP2P7,CYP2D6,CYP2D10,CYP2D26,CYP3A7,CYGB1,NGB |
| iron ion binding | HBE,CYP7A1,HBM,CYP2D10,EGLN3,P4HA1B,HBB-BH1,P4HTM,CYP2D9,CYP2A7 |
| heme binding | HBB-B2,CYP46A1.3,CYP4F22,NOX5,HBM,CYP2K16,SDHC,SUOX,CYP2V1,HBE1 |
| monooxygenase activity | CYP1C2,CYP2K6,CYP2X9,FMO2,YWHAQB,CYP2P10,CYP2B19,CYP1A4,CYP1A,CYP2X10.2 |
| aromatase activity | CYP2C50,CYP2C38,CYP2B19,CYP1A4,CYP1A2,CYP1D1,CYP4X1,CYP2C9,CYP1A1,CYP2A13 |
Interacting Protein
CYP3A5 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CYP3A5 here. Most of them are supplied by our site. Hope this information will be useful for your research of CYP3A5.
CYB5A;ETV5;RDH13;ATOH8
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References
- Uehara, S; Murayama, N; et al. Immunochemical detection of cytochrome P450 enzymes in small intestine microsomes of male and female untreated juvenile cynomolgus monkeys. XENOBIOTICA 44:769-774(2014).
- Uehara, S; Murayama, N; et al. Immunochemical quantification of cynomolgus CYP2J2, CYP4A and CYP4F enzymes in liver and small intestine. XENOBIOTICA 45:124-130(2015).
