Recombinant Human CYP26B1, His-tagged

• Cat.No.: CYP26B1-11769H
• Product Overview: Recombinant Human CYP26B1 protein, fused to His-tag, was expressed in E.coli and purified by Ni-sepharose.

Specification

• Species: Human
• Source: E.coli
• Tag: His
• Protein Length: 104-300a.a.
• Description: This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases that catalyze many reactions involved in drug metabolism and the synthesis of cholesterol, steroids and other lipids. The enzyme encoded by this gene is involved in the specific inactivation of all-trans-retinoic acid to hydroxylated forms, such as 4-oxo-, 4-OH-, and 18-OH-all-trans-retinoic acid.
• Storage: The protein is stored in PBS buffer at -20℃. Avoid repeated freezing and thawing cycles.
• Storage Buffer: 1M PBS (58mM Na2HPO4,17mM NaH2PO4, 68mM NaCl, pH8. ) added with 300mM Imidazole and 0.7% Sarcosyl, 15%glycerol.

Gene Information

• Gene Name: CYP26B1 cytochrome P450, family 26, subfamily B, polypeptide 1 [ Homo sapiens ]
• Official Symbol: CYP26B1
• Synonyms: CYP26B1; cytochrome P450, family 26, subfamily B, polypeptide 1; cytochrome P450 26B1; P450RAI 2; cytochrome P450 26A2; cytochrome P450RAI-2; cytochrome P450 CYP26B1 variant 2; retinoic acid-metabolizing cytochrome; cytochrome P450 retinoic acid-inactivating 2; cytochrome P450 retinoid metabolizing protein; RHFCA; CYP26A2; P450RAI2; P450RAI-2; MGC129613; DKFZp686G0638
• Gene ID: 56603
• mRNA Refseq: NM_019885
• Protein Refseq: NP_063938
• MIM: 605207
• UniProt ID: Q9NR63
• Chromosome Location: 2p12
• Pathway: Adipogenesis, organism-specific biosystem; Biological oxidations, organism-specific biosystem; Cytochrome P450 - arranged by substrate type, organism-specific biosystem; Metabolism, organism-specific biosystem; Phase 1 - Functionalization of compounds, organism-specific biosystem; Retinol metabolism, organism-specific biosystem; Retinol metabolism, conserved biosystem
• Function: electron carrier activity; heme binding; metal ion binding; retinoic acid 4-hydroxylase activity; retinoic acid binding