CYP26B1
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Official Full Name
cytochrome P450, family 26, subfamily B, polypeptide 1 -
Overview
This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases that catalyze many reactions involved in drug metabolism and the synthesis of cholesterol, steroids and other lipids. The enzyme encoded by this gene is involved in the specific inactivation of all-trans-retinoic acid to hydroxylated forms, such as 4-oxo-, 4-OH-, and 18-OH-all-trans-retinoic acid. -
Synonyms
CYP26B1;cytochrome P450, family 26, subfamily B, polypeptide 1;cytochrome P450 26B1;P450RAI 2;CP26;CYP26A2;Cytochrome P450 26A2;Cytochrome P450 family 26 subfamily B polypeptide 1;Cytochrome P450 retinoic acid-inactivating 2;Cytochrome P450 retinoid metabolizing protein;Cytochrome P450RAI-2;DKFZp686G0638;EC 1.14.;MGC129613;P450 26A2;P450 retinoic acid inactivating 2;Retinoic acid metabolizing cytochrome;OTTHUMP00000160175;cytochrome P450 CYP26B1 variant 2;retinoic acid-metabolizing cytochrome;P450RAI-2
Recombinant Proteins
- Human
- Zebrafish
- Rat
- E.coli
- Mammalian Cells
- Wheat Germ
- HEK293
- In Vitro Cell Free System
- His
- GST
- His&T7
- Non
- His&Fc&Avi
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| CYP26B1-11769H | Recombinant Human CYP26B1, His-tagged | E.coli | Human | His | 104-300a.a. | |
| CYP26B1-11942Z | Recombinant Zebrafish CYP26B1 | Mammalian Cells | Zebrafish | His |
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| CYP26B1-1720R | Recombinant Rat CYP26B1 Protein | Mammalian Cells | Rat | His |
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| CYP26B1-2250H | Recombinant Human CYP26B1 Protein, GST-tagged | Wheat Germ | Human | GST |
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| CYP26B1-8074H | Recombinant Human CYP26B1 protein, His & T7-tagged | E.coli | Human | His&T7 | Met1~Val512 |
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| CYP26B1-7120HCL | Recombinant Human CYP26B1 293 Cell Lysate | HEK293 | Human | Non |
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| CYP26B1-01H | Recombinant Human CYP26B1 Protein, His-Tagged | E.coli | Human | His |
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| CYP26B1-1379R | Recombinant Rat CYP26B1 Protein, His (Fc)-Avi-tagged | HEK293 | Rat | His&Fc&Avi |
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| CYP26B1-1379R-B | Recombinant Rat CYP26B1 Protein Pre-coupled Magnetic Beads | HEK293 | Rat |
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| CYP26B1-2167H | Recombinant Human CYP26B1 Protein (Met1-Val512), N-His tagged | E.coli | Human | His | Met1-Val512 |
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| CYP26B1-2325HF | Recombinant Full Length Human CYP26B1 Protein, GST-tagged | In Vitro Cell Free System | Human | GST | Full L. 512 amino acids |
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Involved Pathway
CYP26B1 involved in several pathways and played different roles in them. We selected most pathways CYP26B1 participated on our site, such as Retinol metabolism,Metabolic pathways, which may be useful for your reference. Also, other proteins which involved in the same pathway with CYP26B1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Retinol metabolism | ADH2-2,DGAT1,CYP4A12A,BCO1,RDH8A,CYP2C50,Aldh1a7,UGT2A1,UGT1A6A,CYP2C39 |
| Metabolic pathways | PPT2,HMGCRA,IDI2,PYGM,CYP3A7,ENOPH1,CMAS,AGLA,LIPT1,PPAP2C |
Protein Function
CYP26B1 has several biochemical functions, for example, heme binding,iron ion binding,retinoic acid 4-hydroxylase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by CYP26B1 itself. We selected most functions CYP26B1 had, and list some proteins which have the same functions with CYP26B1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| retinoic acid 4-hydroxylase activity | CYP26A1 |
| iron ion binding | TMLHE,HBE1,CYP19A1A,CYP1C2,CYP2C54,HBBE1.1,CYP4F3,CYP1A2,ALOX5A,CYP2X9 |
| heme binding | CYP2J5,SDHDA,CYP3C1,CYP2P9,CYP1D1,CYP2AA8,TDO2,HBBE3,CYP19A1A,CYB5A |
| retinoic acid binding | CRABP1B,UGT1A3,RARA,CRABP1,UGT1A1,UGT1A9,CRABP2A,CRABP2B,CRABP2,UGT1A2 |
Interacting Protein
CYP26B1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CYP26B1 here. Most of them are supplied by our site. Hope this information will be useful for your research of CYP26B1.
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