Recombinant Human CUBN Protein, His-tagged

• Cat.No.: CUBN-641H
• Product Overview: Recombinant Human CUBN(Cys3157~Met3274) fused with His tag at N-terminal was expressed in E. coli.

Specification

• Species: Human
• Source: E.coli
• Tag: His
• Protein Length: Cys3157~Met3274
• Description: Cubilin (CUBN) acts as a receptor for intrinsic factor-vitamin B12 complexes. The role of receptor is supported by the presence of 27 CUB domains. Cubulin is located within the epithelium of intestine and kidney. Mutations in CUBN may play a role in autosomal recessive megaloblastic anemia.
• Form: PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
• Molecular Mass: 14.4kDa
• Endotoxin: <1.0EU per 1ug (determined by the LAL method)
• Purity: > 95%
• Applications: Positive Control; Immunogen; SDS-PAGE; WB.
  If bio-activity of the protein is needed, please check active protein
• Stability: The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37 centigrade for 48h, and no obvious degradation and precipitation were observed. The loss rate is less than 5% within the expiration date under appropriate storage condition.
• Storage: Avoid repeated freeze/thaw cycles. Store at 2-8 centigrade for one month. Aliquot and store at -80 centigrade for 12 months.
• Reconstitution: Reconstitute in PBS (pH7.4) to a concentration of 0.1-1.0 mg/mL. Do not vortex.

Gene Information

• Gene Name: CUBN cubilin (intrinsic factor-cobalamin receptor) [ Homo sapiens ]
• Official Symbol: CUBN
• Synonyms: CUBN; cubilin (intrinsic factor-cobalamin receptor); MGA1; cubilin; gp280; IFCR; 460 kDa receptor; cubilin precursor variant 1; cubilin precursor variant 2; intrinsic factor B12-receptor; intrinsic factor-cobalamin receptor; intestinal intrinsic factor receptor; intrinsic factor-vitamin B12 receptor; FLJ90055; FLJ90747
• Gene ID: 8029
• mRNA Refseq: NM_001081
• Protein Refseq: NP_001072
• MIM: 602997
• UniProt ID: O60494