CUBN
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Official Full Name
cubilin (intrinsic factor-cobalamin receptor) -
Overview
Cubilin (CUBN) acts as a receptor for intrinsic factor-vitamin B12 complexes. The role of receptor is supported by the presence of 27 CUB domains. Cubulin is located within the epithelium of intestine and kidney. Mutations in CUBN may play a role in autosomal recessive megaloblastic anemia. [provided by RefSeq, Jul 2008] -
Synonyms
CUBN;cubilin (intrinsic factor-cobalamin receptor);IFCR;MGA1;gp280;cubilin;460 kDa receptor;cubilin precursor variant 1;cubilin precursor variant 2;intestinal intrinsic factor receptor;intrinsic factor-vitamin B12 receptor
Recombinant Proteins
- Rat
- Mouse
- Human
- Mammalian Cells
- HEK293
- E.coli
- His
- His&Fc&Avi
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| CUBN-1676R | Recombinant Rat CUBN Protein | Mammalian Cells | Rat | His |
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| CUBN-4073M | Recombinant Mouse CUBN Protein | Mammalian Cells | Mouse | His |
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| CUBN-1335R | Recombinant Rat CUBN Protein, His (Fc)-Avi-tagged | HEK293 | Rat | His&Fc&Avi |
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| CUBN-1335R-B | Recombinant Rat CUBN Protein Pre-coupled Magnetic Beads | HEK293 | Rat |
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| CUBN-2079M | Recombinant Mouse CUBN Protein, His (Fc)-Avi-tagged | HEK293 | Mouse | His&Fc&Avi |
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| CUBN-2079M-B | Recombinant Mouse CUBN Protein Pre-coupled Magnetic Beads | HEK293 | Mouse |
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| CUBN-2226H | Recombinant Human CUBN Protein (Cys3511-Ser3623), N-His tagged | E.coli | Human | His | Cys3511-Ser3623 |
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| CUBN-2473H | Recombinant Human CUBN protein(391-930 aa), C-His-tagged | E.coli | Human | His | 391-930 aa |
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| CUBN-641H | Recombinant Human CUBN Protein, His-tagged | E.coli | Human | His | Cys3157~Met3274 |
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| Cubn-643M | Recombinant Mouse Cubn Protein, His-tagged | E.coli | Mouse | His | Cys3157~Val3274 |
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| Cubn-645R | Recombinant Rat Cubn Protein, His-tagged | E.coli | Rat | His | Cys3157~Val3274 |
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Involved Pathway
CUBN involved in several pathways and played different roles in them. We selected most pathways CUBN participated on our site, such as Vitamin digestion and absorption, which may be useful for your reference. Also, other proteins which involved in the same pathway with CUBN were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Vitamin digestion and absorption | APOA4,APOB,LMBRD1,SLC23A1,SLC19A2,RBP2,FOLH1,SLC5A6,BTD,SCARB1 |
Protein Function
CUBN has several biochemical functions, for example, calcium ion binding,cobalamin binding,cobalamin transporter activity. Some of the functions are cooperated with other proteins, some of the functions could acted by CUBN itself. We selected most functions CUBN had, and list some proteins which have the same functions with CUBN. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| cobalamin binding | MMACHC,CD320,TCNL,TCN2,TCN1,LMBRD1,MUT,GIF |
| receptor activity | CD244,PVRL1B,TNFRSF6B,IL10RB,SLC20A2,GUCY1B3,BTLA,MCC,TNFRSF25,PAQR5B |
| protein homodimerization activity | NUDT16,ATIC,GIMAP7,GNB2L1,RBM11,RCHY1,HPGDS,IMPA1,GSTM3,STC2 |
| hemoglobin binding | LRP2,AHSP,HBB,HP,HPR |
| metal ion binding | MGAT1,FBXL19,TEC,ANTXRL,CYP7A1A,INSM1A,AOX3,PAPD7,TRP63,ANTXR2B |
| identical protein binding | DHX8,SEPT7,CLDN6,ATG101,ALAD,DACT3,PDCD6,INS,CXADR,ATL2 |
| calcium ion binding | PNLIPRP2,GSNB,PCDHA9,CDH7,NOX5,SLIT3,SERPINB1A,CAPSLA,DLC,ITSN2A |
| protein binding | ZSCAN1,RGP1,TRIP10,DSG1A,PRPF31,GAP43,DDI1,TAF1B,CAPN2,PIKFYVE |
Interacting Protein
CUBN has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CUBN here. Most of them are supplied by our site. Hope this information will be useful for your research of CUBN.
Pou5f1;Hsd3b4
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