Recombinant Human CTSL1, GST-tagged

• Cat.No.: CTSL1-11690H
• Product Overview: Recombinant Human CTSL1 protein, fused to GST-tag, was expressed in E.coli and purified by GSH-sepharose.

Specification

• Species: Human
• Source: E.coli
• Tag: GST
• Protein Length: 1-333a.a.
• Description: The protein encoded by this gene is a lysosomal cysteine proteinase that plays a major role in intracellular protein catabolism. Its substrates include collagen and elastin, as well as alpha-1 protease inhibitor, a major controlling element of neutrophil elastase activity. The encoded protein has been implicated in several pathologic processes, including myofibril necrosis in myopathies and in myocardial ischemia, and in the renal tubular response to proteinuria. This protein, which is a member of the peptidase C1 family, is a dimer composed of disulfide-linked heavy and light chains, both produced from a single protein precursor. Multiple alternatively spliced transcript variants have been found for this gene.
• Storage: The protein is stored in PBS buffer at -20℃. Avoid repeated freezing and thawing cycles.
• Storage Buffer: 1M PBS (58mM Na2HPO4,17mM NaH2PO4, 68mM NaCl, pH8. ) added with 100mM GSH and 1% Triton X-100,15%glycerol.

Gene Information

• Gene Name: CTSL1 cathepsin L1 [ Homo sapiens ]
• Official Symbol: CTSL1
• Synonyms: CTSL1; cathepsin L1; cathepsin L , CTSL; FLJ31037; cathepsin L; major excreted protein; MEP; CATL; CTSL
• Gene ID: 1514
• mRNA Refseq: NM_001257971
• Protein Refseq: NP_001244900
• MIM: 116880
• UniProt ID: P07711
• Chromosome Location: 9q21.33
• Pathway: Antigen processing and presentation, organism-specific biosystem; Antigen processing and presentation, conserved biosystem; Immune System, organism-specific biosystem; Innate Immune System, organism-specific biosystem; Lysosome, organism-specific biosystem; Lysosome, conserved biosystem; Phagosome, organism-specific biosystem
• Function: cysteine-type endopeptidase activity; cysteine-type endopeptidase activity; cysteine-type peptidase activity; histone binding; peptidase activity; protein binding