CTSL1

  • Official Full Name

    cathepsin L1

  • Overview

    Cathepsin L is a lysosomal endopeptidase belonging to the papain cysteine protease superfamily. Macrophages and osteoclasts secrete the precursor of cathepsin L, procathepsin L, which is processed to some form of active enzyme by acid, surface activation, or proteolysis. It is then involved in connective tissue degradation and the turnover of extracellular matrix proteins. Procathepsin L is also secreted by many malignantly transformed cells, mRNA, and its protein expression levels, as well as the extent to which it is secreted are correlated to the malignant potential of these cells. As cathepsin L is capable of degrading protein constituents of the extracellular matrix, it may play a crucial role in tumor progression, metastasis, and other disorders involving the destruction of the extracellular matrix. Inhibition of the enzyme or the proenzyme by low molecular weight inhibitors or antibodies and in vivo lead to a suppression of the invasiveness of malignant cells or a decline in their ability to form tumors.

  • Synonyms

    RP11-65B23.1;CATL;CTSL;MEP;cathepsin L;major excreted protein

Recombinant Proteins

  • Human
  • Rat
  • Chlorocebus Aethiops
  • E.coli
  • HEK293
  • Mammalian Cell
  • Human Cell
  • Human Liver
  • GST
  • His
  • Non
  • His&Fc&Avi
  • His&SUMO
Cat.# Product name Source (Host) Species Tag Protein Length Price
CTSL1-11690H Recombinant Human CTSL1, GST-tagged E.coli Human GST 1-333a.a.
CTSL1-896H Recombinant Human CTSL1 protein(Thr 18 - Val 333) HEK293 Human His Thr 18 - Val 333
CTSL1-1668R Recombinant Rat CTSL1 Protein Mammalian Cell Rat His
CTSL1-26491TH Recombinant Human CTSL1, His-tagged E.coli Human His Full L.
CTSL1-91H Recombinant Human cathepsin L1 E.coli Human Non 1-87 a.a.
CTSL1-3022HCL Recombinant Human CTSL1 cell lysate Human Cell Human Non
CTSL1-1327R Recombinant Rat CTSL1 Protein, His (Fc)-Avi-tagged HEK293 Rat His&Fc&Avi
CTSL1-1327R-B Recombinant Rat CTSL1 Protein Pre-coupled Magnetic Beads HEK293 Rat
CTSL1-1859H Native Human Cathepsin L1 Human Liver Human Non
CTSL1-27406TH Native Human CTSL1 Human Non Full L.
CTSL1-441C Recombinant Chlorocebus Aethiops CTSG Protein (114-333 aa), His-SUMO-tagged E.coli Chlorocebus Aethiops His&SUMO 114-333 aa

    Involved Pathway

    CTSL1 involved in several pathways and played different roles in them. We selected most pathways CTSL1 participated on our site, such as Adaptive Immune System,Antigen processing and presentation,Antigen processing-Cross presentation, which may be useful for your reference. Also, other proteins which involved in the same pathway with CTSL1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Assembly of collagen fibrils and other multimeric structures COL1A1,MMP13,COL5A2,COL10A1,COL8A1,COL4A4,LOXL4,BMP1A,COL5A3B,COL8A2
    Class I MHC mediated antigen processing &amp UBE2V2,TRIM63,RNF182,ASB9,RNF138,FBXO44,RNF6,CYBB,DTX3L,RNF19B
    presentation UBE2F,LRSAM1,FBXO3,CTSL2,ASB9,PJA1,SPSB2,LRRC41,TPP2,RBCK1
    Collagen degradation COL9A1,MMP10,MMP13,MGC174155,COL19A1,MMP11,COL17A1,CTS7,MGC174857,MMP15
    Antigen processing and presentation B2M,HSPA8,HLA-DRA,H2-AA,KIR2DS2,IFI30,Ctsl,HSPA2,KIR2DL1,HLA-DPA1
    Adaptive Immune System DTX3L,LRRC41,LAIR1,KIF15,AP2A1,DCTN2,RAPGEF3,CD160,FCGR1B,HLA-DQB2
    Degradation of the extracellular matrix ADAM8,KLK7,CTSL2,CTRB1,ACAN,TPSAB1,CTSD,TIMP2A,EMID2,NID1
    Collagen formation LEPRE1,COL8A1A,CTSB,LOXL3,PRP,COL4A4,COL10A1,COL9A3,LOXL4,PCOLCEA
    Antigen processing-Cross presentation CYBB,SEC61B,CD207,CTSS,CYBA,FCGR1B,CTSL2

    Protein Function

    CTSL1 has several biochemical functions, for example, collagen binding,cysteine-type endopeptidase activity,cysteine-type peptidase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by CTSL1 itself. We selected most functions CTSL1 had, and list some proteins which have the same functions with CTSL1. You can find most of the proteins on our site.

    Function Related Protein
    collagen binding ITGA1,ACHE,GP6,DCN,GP5,TGFBI,CD44,MRC2,MMP13,PAK1
    histone binding HIST1H4A,HIST1H4F,CD1D,ATRX,SUPT6H,PIH1D1,SPTY2D1,BRD1,DAXX,MCM2
    fibronectin binding ITGA3,ITGAV,THBS1,ITGB3,LRRC15,CTGF,FSTL3,ITGB1,IGFBP3,PLEKHA2
    cysteine-type endopeptidase activity CTSK,CTSL1B,CTLA2B,USP19,USP50,CTSBB,CASP8,CTSB,Ctsl,USP28
    protein binding ZNF83,SUPT5H,PPIL2,RYR1B,ICA1,AGTR1A,PIK3CB,DNAJC10,FAM65B,LATS1
    cysteine-type peptidase activity CTSBB,CAPN3B,Ctsl,SENP3A,CTSW,PGPEP1,CASP6L2,OTUD6B,CAPN3A,CLCA3
    proteoglycan binding THBS1,CTSK,CTSB,CECR1,UBE4A,SLIT2,FCN2,CTSS,CECR1A,NID1

    Interacting Protein

    CTSL1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CTSL1 here. Most of them are supplied by our site. Hope this information will be useful for your research of CTSL1.

    SGTA;srp-6;BTN3A3;EED;PPP1CC;GEM;RELB;CRELD2;alsS;IGHA1;APOA1;ALB;TF;cona_canen

    Resources

    References

    • Mas-Coma, S; Bargues, MD; et al. Diagnosis of human fascioliasis by stool and blood techniques: update for the present global scenario. PARASITOLOGY 141:1918-1946(2014).
    • Toet, H; Piedrafita, DM; et al. Liver fluke vaccines in ruminants: strategies, progress and future opportunities. INTERNATIONAL JOURNAL FOR PARASITOLOGY 44:915-927(2014).

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