Recombinant Human CTNNB1,GST-tagged

• Cat.No.: CTNNB1-1441H
• Product Overview: Recombinant full-length human Catenin beta was expressed by baculovirus inSf9 insect cellsusing an N-terminal GST tag. MW = 115kDa.

Specification

• Species: Human
• Source: Sf9 Cells
• Tag: GST
• Description: β-catenins are cytoplasmic proteins that are ubiquitously expressed. These proteins associate with E-cadherin at cellular junctions. β-catenin interacts with TCF and LEF transcription factors and is an essential member of the Wingless-Wnt signal transduction pathway. The adenomatous polyposis coli (APC) tumor-suppressor protein, together with Axin and GSK3β, form a Wnt-regulated signaling complex that mediates phosphorylation-dependent degradation of β-catenin by the proteasome. APC and Siah-1 mediate a novel β-catenin degradation pathway linking p53 activation to cell cycle control. Activating mutations in the human β-catenin gene have been found in human colon cancer and melanomas.
• Sequence: Full-length.
• Applications: Western Blot.
• Storage And Stability: Store product at -70℃. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.

Gene Information

• Gene Name: CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa [ Homo sapiens ]
• Synonyms: CTNNB1; catenin (cadherin-associated protein), beta 1, 88kDa; CTNNB; FLJ25606; FLJ37923; DKFZp686D02253; beta-catenin; Catenin beta-1; Beta-catenin
• Gene ID: 1499
• mRNA Refseq: NM_001098209
• Protein Refseq: NP_001091679
• MIM: 116806
• UniProt ID: P35222
• Chromosome Location: 3p21
• Pathway: Adherens junction; Arrhythmogenic right ventricular cardiomyopathy (ARVC); Basal cell carcinoma; Colorectal cancer; Endometrial cancer; Focal adhesion; Leukocyte transendothelial migration; Melanogenesis; Pathogenic Escherichia coli infection; Pathways in cancer; Prostate cancer; Thyroid cancer; Tight junction; Wnt signaling pathway; Apoptosis; Cell-cell adhesion systems; Signaling by Wnt
• Function: I-SMAD binding; alpha-catenin binding; androgen receptor binding; cadherin binding; chromatin binding; double-stranded DNA binding; kinase binding; promoter binding; protein C-terminus binding; protein phosphatase binding; signal transducer activity; transcription coactivator activity; transcription factor activity; transcription factor binding