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Description :	The protein encoded by this gene is part of a complex of proteins that constitute adherens junctions (AJs). AJs are necessary for the creation and maintenance of epithelial cell layers by regulating cell growth and adhesion between cells. The encoded protein also anchors the actin cytoskeleton and may be responsible for transmitting the contact inhibition signal that causes cells to stop dividing once the epithelial sheet is complete. Finally, this protein binds to the product of the APC gene, which is mutated in adenomatous polyposis of the colon. Mutations in this gene are a cause of colorectal cancer (CRC), pilomatrixoma (PTR), medulloblastoma (MDB), and ovarian cancer. Alternative splicing results in multiple transcript variants.
Source :	Sf9
Species :	Human
Tag :	Flag
Form :	50mM Tris-HCl, pH8.0, 100mM glycine, 10% glycerol.
Molecular Mass :	85 kDa
AA Sequence :	A DNA sequence from TrueORF clone, RC208947, encoding human full-length CTNNB1.
Purity :	> 80% as determined by SDS-PAGE and Coomassie blue staining.
Stability :	Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.
Storage :	Store at -80 centigrade.
Concentration :	>50 ug/mL as determined by microplate BCA method.
Preparation :	Recombinant protein was captured through anti-DDK affinity column followed by conventional chromatography steps.
Protein Families :	Druggable Genome, ES Cell Differentiation/IPS, Transcription Factors
Protein Pathways :	Adherens junction, Arrhythmogenic right ventricular cardiomyopathy (ARVC), Basal cell carcinoma, Colorectal cancer, Endometrial cancer, Focal adhesion, Leukocyte transendothelial migration, Melanogenesis, Pathogenic Escherichia coli infection, Pathways in cancer, Prostate cancer, Thyroid cancer, Tight junction, Wnt signaling pathway
Full Length :	Full L.

Gene Name	CTNNB1 catenin beta 1 [ Homo sapiens (human) ]
Official Symbol	CTNNB1
Synonyms	EVR7; CTNNB; MRD19; NEDSDV; armadillo
Gene ID	1499
mRNA Refseq	NM_001904.4
Protein Refseq	NP_001895.1
MIM	116806
UniProt ID	P35222