Recombinant Human CSE1L protein, MYC/DDK-tagged

• Cat.No.: CSE1L-9523H
• Product Overview: Recombinant Human CSE1L fused with MYC/DDK tag at C-terminal was expressed in HEK293.

Specification

• Species: Human
• Source: HEK293
• Tag: DDK&Myc
• Description: Proteins that carry a nuclear localization signal (NLS) are transported into the nucleus by the importin-alpha/beta heterodimer. Importin-alpha binds the NLS, while importin-beta mediates translocation through the nuclear pore complex. After translocation, RanGTP binds importin-beta and displaces importin-alpha. Importin-alpha must then be returned to the cytoplasm, leaving the NLS protein behind. The protein encoded by this gene binds strongly to NLS-free importin-alpha, and this binding is released in the cytoplasm by the combined action of RANBP1 and RANGAP1. In addition, the encoded protein may play a role both in apoptosis and in cell proliferation. Alternatively spliced transcript variants have been found for this gene.
• Form: 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol.
• Molecular Mass: 110.2 kDa
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining
• Storage: Store at -80 centigrade. Aliquot to avoid repeated freezing and thawing.
• Concentration: >50 ug/mL as determined by microplate BCA method

Gene Information

• Gene Name: CSE1L CSE1 chromosome segregation 1-like (yeast) [ Homo sapiens ]
• Official Symbol: CSE1L
• Synonyms: CSE1L; CSE1 chromosome segregation 1-like (yeast); chromosome segregation 1 (yeast homolog) like; exportin-2; CAS; CSE1; XPO2; exp2; importin-alpha re-exporter; chromosome segregation 1-like protein; cellular apoptosis susceptibility protein; MGC117283; MGC130036; MGC130037
• Gene ID: 1434
• mRNA Refseq: NM_001316
• Protein Refseq: NP_001307
• MIM: 601342
• UniProt ID: P55060
• Chromosome Location: 20q13
• Pathway: Direct p53 effectors, organism-specific biosystem; p53 pathway, organism-specific biosystem
• Function: importin-alpha export receptor activity; protein binding; protein transporter activity