CSE1L

  • Official Full Name

    CSE1 chromosome segregation 1-like

  • Overview

    Proteins that carry a nuclear localization signal (NLS) are transported into the nucleus by the importin-alpha/beta heterodimer. Importin-alpha binds the NLS, while importin-beta mediates translocation through the nuclear pore complex. After translocation, RanGTP binds importin-beta and displaces importin-alpha. Importin-alpha must then be returned to the cytoplasm, leaving the NLS protein behind. The protein encoded by this gene binds strongly to NLS-free importin-alpha, and this binding is released in the cytoplasm by the combined action of RANBP1 and RANGAP1. In addition, the encoded protein may play a role both in apoptosis and in cell proliferation.

  • Synonyms

    CSE1L;CSE1 chromosome segregation 1-like (yeast);chromosome segregation 1 (yeast homolog) like;exportin-2;CAS;CSE1;XPO2;exp2;importin-alpha re-exporter;chromosome segregation 1-like protein;cellular apoptosis susceptibility protein;MGC117283;M

Recombinant Proteins

  • Rhesus macaque
  • Zebrafish
  • Human
  • Mammalian Cells
  • Wheat Germ
  • HEK293
  • In Vitro Cell Free System
  • E.coli
  • His
  • GST
  • Non
  • Myc&DDK
  • Flag
  • His&SUMO
  • His&Fc&Avi
Cat.# Product name Source (Host) Species Tag Protein Length Price
CSE1L-1049R Recombinant Rhesus monkey CSE1L Protein, His-tagged Mammalian Cells Rhesus macaque His
CSE1L-11497Z Recombinant Zebrafish CSE1L Mammalian Cells Zebrafish His
CSE1L-1959H Recombinant Human CSE1L Protein, GST-tagged Wheat Germ Human GST
CSE1L-27394TH Recombinant Human CSE1L Wheat Germ Human Non 100 amino acids
CSE1L-27953TH Recombinant Human CSE1L Wheat Germ Human Non 195 amino acids
CSE1L-9523H Recombinant Human CSE1L protein, MYC/DDK-tagged HEK293 Human Myc&DDK
CSE1L-9523HCL Recombinant Human CSE1L Over-expression Cell Lysate HEK293 Human Myc&DDK
CSE1L-212HFL Recombinant Full Length Human CSE1L Protein, C-Flag-tagged Mammalian Cells Human Flag Full L.
CSE1L-2152HF Recombinant Full Length Human CSE1L Protein, GST-tagged In Vitro Cell Free System Human GST Full L. 195 amino acids
CSE1L-2363H Recombinant Human CSE1L protein, His-SUMO-tagged E.coli Human His&SUMO 1-200aa
CSE1L-2732H Recombinant Human CSE1L Protein (1-200 aa), His-SUMO-tagged E.coli Human His&SUMO 1-200 aa
CSE1L-670H Recombinant Human CSE1L Protein, His (Fc)-Avi-tagged HEK293 Human His&Fc&Avi
CSE1L-670H-B Recombinant Human CSE1L Protein Pre-coupled Magnetic Beads HEK293 Human
CSE1L-874R Recombinant Rhesus Macaque CSE1L Protein, His (Fc)-Avi-tagged HEK293 Rhesus macaque His&Fc&Avi
CSE1L-874R-B Recombinant Rhesus Macaque CSE1L Protein Pre-coupled Magnetic Beads HEK293 Rhesus macaque
CSE1L-95HF Recombinant Full Length Human CSE1L Protein In Vitro Cell Free System Human Full L. 195 amino acids

    Involved Pathway

    CSE1L involved in several pathways and played different roles in them. We selected most pathways CSE1L participated on our site, such as Direct p53 effectors,p53 pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with CSE1L were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    p53 pathway CSNK1G3,RASSF1,SMYD2,FBXO11,HUWE1,KAT8,PPP1R13L,TRIM28,NEDD8,TTC5
    Direct p53 effectors EPHA2,EDN2,AIFM2,GDF15,DUSP5,BNIP3L,PRDM1,HIC1,PPM1J,CD82

    Protein Function

    CSE1L has several biochemical functions, for example, Ran GTPase binding,nuclear export signal receptor activity,protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by CSE1L itself. We selected most functions CSE1L had, and list some proteins which have the same functions with CSE1L. You can find most of the proteins on our site.

    Function Related Protein
    protein binding SPINLW1,PIDD1,TBC1D20,SH3GL1,LCA5,GJA4,ZFP64,KLRB1F,NSUN4,CDC42EP1
    nuclear export signal receptor activity XPO4,NUPL2,XPO7
    Ran GTPase binding RANBP3,IPO13,TNPO1,IPO11,RANBP10,RANGAP1,XPO5,BIRC5,XPO1,TNPO2

    Interacting Protein

    CSE1L has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CSE1L here. Most of them are supplied by our site. Hope this information will be useful for your research of CSE1L.

    TP53;1-phosphatidyl-1d-myo-inositol 3,5-bisphosphate;1-phosphatidyl-1d-myo-inositol 4,5-bisphosphate;LRRK2;USP19;TNFRSF1B;NRIP1;YWHAG;YWHAZ;IKBKG;HNRNPL;RPL22;PPP5C

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