Recombinant Human CRTC2, GST-tagged

• Cat.No.: CRTC2-11594H
• Product Overview: Recombinant Human CRTC2 protein, fused to GST-tag, was expressed in E.coli and purified by GSH-sepharose.

Specification

• Species: Human
• Source: E.coli
• Tag: GST
• ProteinLength: C-term-300a.a.
• Description: This gene encodes a member of the transducers of regulated cAMP response element-binding protein activity family of transcription coactivators. These proteins promote the transcription of genes targeted by the cAMP response element-binding protein, and therefore play an important role in many cellular processes. Under basal conditions the encoded protein is phosphorylated by AMP-activated protein kinase or the salt-inducible kinases and is sequestered in the cytoplasm. Upon activation by elevated cAMP or calcium, the encoded protein translocates to the nucleus and increases target gene expression. Single nucleotide polymorphisms in this gene may increase the risk of type 2 diabetes. A pseudogene of this gene is located on the long arm of chromosome 5.
• Storage: The protein is stored in PBS buffer at -20℃. Avoid repeated freezing and thawing cycles.
• Storage Buffer: 1M PBS (58mM Na2HPO4,17mM NaH2PO4, 68mM NaCl, pH8. ) added with 100mM GSH and 1% Triton X-100,15%glycerol

Gene Information

• Gene Name: CRTC2 CREB regulated transcription coactivator 2 [ Homo sapiens ]
• Official Symbol: CRTC2
• Synonyms: CRTC2; CREB regulated transcription coactivator 2; CREB-regulated transcription coactivator 2; TORC2; transducer of regulated cAMP response element-binding protein (CREB) 2; TORC-2
• Gene ID: 200186
• mRNA Refseq: NM_181715
• Protein Refseq: NP_859066
• MIM: 608972
• UniProt ID: Q53ET0
• Chromosome Location: 1q21.3
• Pathway: AMPK signaling, organism-specific biosystem; HTLV-I infection, organism-specific biosystem; HTLV-I infection, conserved biosystem; LKB1 signaling events, organism-specific biosystem
• Function: cAMP response element binding protein binding