Recombinant Human CRISP2, His-tagged

• Cat.No.: CRISP2-7683H
• Product Overview: Recombinant Human CysteineRich Secretory Protein 2/CRISP2 is produced with our mammalian cells expression system in HEK293. The target protein is expressed with sequence (Lys22Tyr243) of Human CRISP2 fused with a polyhistidine tag at the Cterminus.

Specification

• Species: Human
• Source: HEK293
• Tag: His
• Description: CysteineRich Secretory Protein 2 (CRISP2) is a member of the CRISP subdivision of the CAP superfamily, which is defined by a CAP signature motif common to the entire superfamily, and has been localized to both the sperm acrosome and tail. Within mammals, four CRISPs have been defined: CRISP1 (acidic epididymal glycoprotein [AEG], proteins D and E), CRISP2 (TPX1), CRISP3, and CRISP4. All are strongly expressed within the male reproductive tract, suggesting key roles in male fertility. CRISP2 may regulate some ion channels" activity and therebye regulate calcium fluxes during sperm capacitation.
• Form: Lyophilized from a 0.2 μM filtered solution of 20mM PB, 150mM NaCl, 0.5% CHAPS, pH 7.4
• AA Sequence: KDPAFTALLT TQLQVQREIV NKHNELRKAV SPPASNMLKM EWSREVTTNA QRWANKCTLQ HSDPEDRKT STRCGENLYM SSDPTSWSSA IQSWYDEILD FVYGVGPKSP NAVVGHYTQL V WYSTYQVG CGIAYCPNQD SLKYYYVCQY CPAGNNMNRK NTPYQQGTPC AGCPDDCDKG LC TNSCQYQ DLLSNCDSLK NTAGCEHELL KEKCKATCLC ENKIYVDHHH HHH*
• Purity: Greater than 95% as determined by SEC-HPLC and reducing SDS-PAGE.
• Notes: For research use only.
• Storage: Lyophilized protein should be stored at less than 20°C. though stable at room temperature for 3 weeks.Reconstituted protein solution can be stored at 4-7°C. for 2-7 days.Aliquots of reconstituted samples are stable at less than 20°C. for 3 months.

Gene Information

• Gene Name: CRISP2 cysteine-rich secretory protein 2 [ Homo sapiens ]
• Official Symbol: CRISP2
• Synonyms: CRISP2; cysteine-rich secretory protein 2; GAPDL5, testis specific protein 1 (probe H4 1 p3 1) , TPX1; cancer/testis antigen 36; CRISP 2; CT36; testis-specific protein TPX-1; testis specific protein 1 (probe H4-1 p3-1); glyceraldehyde-3-phosphate dehydrogenase-like 5; TPX1; TSP1; GAPDL5; CRISP-2; MGC111136
• Gene ID: 7180
• mRNA Refseq: NM_001142407
• Protein Refseq: NP_001135879
• MIM: 187430
• UniProt ID: P16562
• Chromosome Location: 6p12.3