Recombinant Human Complement Component 8, Gamma Polypeptide, His-tagged

• Cat.No.: C8G-6880H
• Product Overview: Recombinant human C8G protein, fused to His-tag at N-terminus, was expressed in E. coli and purified by using conventional chromatography techniques. MW: 22.6 kDa.

Specification

• Description: C8G is one of three polypeptides (along with C8 alpha and C8 beta) that constitutes C8, a component of the complement system. C8 participates in the formation of Membrane Attack Complex. Patients with deficiency in C8 are vulnerable to certain bacteria infection. C8gamma is a secreted protein that is able to bind retinol and belongs to the lipocalin family and calycin superfamily.
• Source: E. coli
• Species: Human
• Tag: His
• Form: Liquid. In 20mM Tris-HCl buffer(pH 8.0) containing 10% glycerol, 2mM DTT, 0.15M NaCl.
• Molecular Mass: 22.6 kDa (203aa), confirmed by MALDI-TOF.
• Protein length: 21-202aa
• AA Sequence: MGSSHHHHHH SSGLVPRGSH MQKPQRPRRP ASPISTIQPK ANFDAQQFAG TWLLVAVGSA CRFLQEQGHR AEATTLHVAP QGTAMAVSTF RKLDGICWQV RQLYGDTGVL GRFLLQARGA RGAVHVVVAE TDYQSFAVLY LERAGQLSVK LYARSLPVSD SVLSGFEQRV QEAHLTEDQI FYFPKYGFCE AADQFHVLDE VRR
• Purity: >95% by SDS - PAGE
• Applications: SDS-PAGE
• Storage: Can be stored at 4°C short term (1-2 weeks). For long term storage, aliquot and store at -20°C or -70°C. Avoid repeated freezing and thawing cycles.
• Concentration: 0.5 mg/ml (determined by Bradford)

Gene Information

• Gene Name: C8G complement component 8, gamma polypeptide [ Homo sapiens ]
• Official Symbol: C8G
• Synonyms: C8G; complement component 8, gamma polypeptide; complement component C8 gamma chain; C8C; MGC142186
• Gene ID: 733
• mRNA Refseq: NM_000606
• Protein Refseq: NP_000597
• MIM: 120930
• UniProt ID: P07360
• Chromosome Location: 9q
• Pathway: Amoebiasis, organism-specific biosystem; Amoebiasis, conserved biosystem; Complement and Coagulation Cascades, organism-specific biosystem; Complement and coagulation cascades, organism-specific biosystem; Complement and coagulation cascades, conserved biosystem; Complement cascade, organism-specific biosystem; Immune System, organism-specific biosystem
• Function: binding; complement binding; retinol binding; transporter activity