Recombinant Human COMMD5 Protein, Myc/DDK-tagged, C13 and N15-labeled

• Cat.No.: COMMD5-2691H
• Product Overview: COMMD5 MS Standard C13 and N15-labeled recombinant protein (NP_001074472) with a C-terminal MYC/DDK tag, was expressed in HEK293 cells.

Specification

• Description: May modulate activity of cullin-RING E3 ubiquitin ligase (CRL) complexes. Negatively regulates cell proliferation. Negatively regulates cell cycle G2/M phase transition probably by transactivating p21/CDKN1A through the p53/TP53-independent signaling pathway. Involved in kidney proximal tubule morphogenesis. Down-regulates activation of NF-kappa-B.
• Source: HEK293
• Species: Human
• Tag: Myc&DDK
• Molecular Mass: 24.7 kDa
• AA Sequence: MSAVGAATPYLHHPGDSHSGRVSFLGAQLPPEVAAMARLLGDLDRSTFRKLLKFVVSSLQGEDCREAVQRLGVSANLPEEQLGALLAGMHTLLQQALRLPPTSLKPDTFRDQLQELCIPQDLVGDLASVVFGSQRPLLDSVAQQQGAWLPHVADFRWRVDVAISTSALARSLQPSVLMQLKLSDGSAYRFEVPTAKFQELRYSVALVLKEMADLEKRCERRLQDTRTRPLEQKLISEEDLAANDILDYKDDDDKV
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining
• Stability: Stable for 3 months from receipt of products under proper storage and handling conditions.
• Storage: Store at -80 centigrade. Avoid repeated freeze-thaw cycles.
• Concentration: 50 μg/mL as determined by BCA
• Storage Buffer: 100 mM glycine, 25 mM Tris-HCl, pH 7.3.

Gene Information

• Gene Name: COMMD5 COMM domain containing 5 [ Homo sapiens (human) ]
• Official Symbol: COMMD5
• Synonyms: COMM domain containing 5; FLJ13008; HCaRG; HT002Hypertension-related calcium-regulated gene protein; COMM domain-containing protein 5HCARG; COMMD5
• Gene ID: 28991
• mRNA Refseq: NM_001081003
• Protein Refseq: NP_001074472
• MIM: 608216
• UniProt ID: Q9GZQ3