Recombinant Human CLDN1 Protein, Myc/DDK-tagged, C13 and N15-labeled

• Cat.No.: CLDN1-4298H
• Product Overview: CLDN1 MS Standard C13 and N15-labeled recombinant protein (NP_066924) with a C-terminal MYC/DDK tag, was expressed in HEK293 cells.

Specification

• Description: Tight junctions represent one mode of cell-to-cell adhesion in epithelial or endothelial cell sheets, forming continuous seals around cells and serving as a physical barrier to prevent solutes and water from passing freely through the paracellular space. These junctions are comprised of sets of continuous networking strands in the outwardly facing cytoplasmic leaflet, with complementary grooves in the inwardly facing extracytoplasmic leaflet. The protein encoded by this gene, a member of the claudin family, is an integral membrane protein and a component of tight junction strands. Loss of function mutations result in neonatal ichthyosis-sclerosing cholangitis syndrome.
• Source: HEK293
• Species: Human
• Tag: Myc&DDK
• Molecular Mass: 22.7 kDa
• AA Sequence: MANAGLQLLGFILAFLGWIGAIVSTALPQWRIYSYAGDNIVTAQAMYEGLWMSCVSQSTGQIQCKVFDSLLNLSSTLQATRALMVVGILLGVIAIFVATVGMKCMKCLEDDEVQKMRMAVIGGAIFLLAGLAILVATAWYGNRIVQEFYDPMTPVNARYEFGQALFTGWAAASLCLLGGALLCCSCPRKTTSYPTPRPYPKPAPSSGKDYVTRTRPLEQKLISEEDLAANDILDYKDDDDKV
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining
• Stability: Stable for 3 months from receipt of products under proper storage and handling conditions.
• Storage: Store at -80 centigrade. Avoid repeated freeze-thaw cycles.
• Concentration: 50 μg/mL as determined by BCA
• Storage Buffer: 100 mM glycine, 25 mM Tris-HCl, pH 7.3.

Gene Information

• Gene Name: CLDN1 claudin 1 [ Homo sapiens (human) ]
• Official Symbol: CLDN1
• Synonyms: CLDN1; claudin 1; claudin-1; ILVASC; SEMP1; senescence associated epithelial membrane protein 1; senescence-associated epithelial membrane protein 1; CLD1
• Gene ID: 9076
• mRNA Refseq: NM_021101
• Protein Refseq: NP_066924
• MIM: 603718
• UniProt ID: O95832