CLDN1
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Official Full Name
claudin 1 -
Overview
Tight junctions represent one mode of cell-to-cell adhesion in epithelial or endothelial cell sheets, forming continuous seals around cells and serving as a physical barrier to prevent solutes and water from passing freely through the paracellular space. These junctions are comprised of sets of continuous networking strands in the outwardly facing cytoplasmic leaflet, with complementary grooves in the inwardly facing extracytoplasmic leaflet. The protein encoded by this gene, a member of the claudin family, is an integral membrane protein and a component of tight junction strands. Loss of function mutations result in neonatal ichthyosis-sclerosing cholangitis syndrome. -
Synonyms
CLDN1;claudin 1;claudin-1;ILVASC;SEMP1;senescence associated epithelial membrane protein 1;senescence-associated epithelial membrane protein 1;CLD1
Recombinant Proteins
- Human
- Rat
- Chicken
- Mouse
- Rhesus macaque
- Zebrafish
- Bovine
- Mus musculus
- E.coli
- HEK293
- Wheat Germ
- Mammalian Cell
- Baculovirus-Insect cells
- Mammalian cells
- In Vitro Cell Free System
- HEK293T
- E.coli expression system
- GST
- Non
- His
- His&Fc&Avi
- Flag
- Myc&DDK
- His&GST
Involved Pathway
CLDN1 involved in several pathways and played different roles in them. We selected most pathways CLDN1 participated on our site, such as Cell adhesion molecules (CAMs),Tight junction,Leukocyte transendothelial migration, which may be useful for your reference. Also, other proteins which involved in the same pathway with CLDN1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Cell adhesion molecules (CAMs) | BMA2,ALCAMA,LRRC4C,PVRL1B,MHC2DAB,CD40,CLDN7B,MHC2DEB,CLDN9,HLA-E |
| Leukocyte transendothelial migration | PRKCA,ITGB2,CLDN8,MYL2,BCAR1,RAC1,AASS,CD99,GNAI2,PLCG2 |
| Hepatitis C | OAS1A,IFIT1,CLDN9,IFNA17,PPP2R2C,MAVS,IFNA6,IFNAR1,MAPK9,PIK3CB |
| Pathogenic Escherichia coli infection | CD14,RHOA,TUBB2A,ROCK1,TLR5,TUBB7P,OCLN,NCK2,TUBA1B,ACTB |
| Tight junction | JAM2A,INADL,MYH10,GNAI1,GNAI2,MYH1B,YES1,CLDN7,CASKA,NRAS |
Protein Function
CLDN1 has several biochemical functions, for example, identical protein binding,protein binding,structural molecule activity. Some of the functions are cooperated with other proteins, some of the functions could acted by CLDN1 itself. We selected most functions CLDN1 had, and list some proteins which have the same functions with CLDN1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| identical protein binding | FADD,SMG9,LUC7L,PTPRM,CNTN2,GNPNAT1,CLPP,SF1,PAFAH1B3,DNM1L |
| virus receptor activity | PVRL1,TYRO3,CLEC5A,PVRL2,NCAM1,SCARB2,TFRC,ITGA2,MOG,LDLR |
| protein binding | TFR2,IL4R,FAM83A,CUL9,CDK17,HES1,THAP10,SNRNP27,UQCRB,Serpina1b |
| structural molecule activity | SEMG1,CSTA,KRT1-C5,CLDN8,KRT40,TUBG2,SPRR2D,LMNB2,CLDN11B,CLDN7 |
Interacting Protein
CLDN1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CLDN1 here. Most of them are supplied by our site. Hope this information will be useful for your research of CLDN1.
TACSTD2;INADL;BRD4;DRG1
Resources
Research Area
Tight Junction Proteins in Endothelial CellsTight Junction Proteins in VSMC
Epithelial Cell Markers and Intracellular Molecules
Claudins
Tight Junctions
Related Services
Related Products
References
- Ghosn, J; Fouquet, B; et al. Claudin-1 Gene Variants and Susceptibility to Hepatitis C Infection in HIV-1 Infected Intravenous Drug Users (an ANRS Case-Control Study). JOURNAL OF MEDICAL VIROLOGY 87:619-624(2015).
- Xiao, F; Fofana, I; et al. Synergy of entry inhibitors with direct-acting antivirals uncovers novel combinations for prevention and treatment of hepatitis C. GUT 64:483-+(2015).
