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Description :	Tight junctions represent one mode of cell-to-cell adhesion in epithelial or endothelial cell sheets, forming continuous seals around cells and serving as a physical barrier to prevent solutes and water from passing freely through the paracellular space. These junctions are comprised of sets of continuous networking strands in the outwardly facing cytoplasmic leaflet, with complementary grooves in the inwardly facing extracytoplasmic leaflet. The protein encoded by this gene, a member of the claudin family, is an integral membrane protein and a component of tight junction strands. Loss of function mutations result in neonatal ichthyosis-sclerosing cholangitis syndrome.
Source :	E. coli
Species :	Human
Tag :	His&GST
Form :	PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
Molecular Mass :	48.1kDa
Protein length :	Leu50~Arg197
Endotoxin :	<1.0EU per 1ug (determined by the LAL method)
Purity :	> 95%
Applications :	Positive Control; Immunogen; SDS-PAGE; WB. If bio-activity of the protein is needed, please check active protein
Stability :	The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37 centigrade for 48h, and no obvious degradation and precipitation were observed. The loss rate is less than 5% within the expiration date under appropriate storage condition.
Storage :	Avoid repeated freeze/thaw cycles. Store at 2-8 centigrade for one month. Aliquot and store at -80 centigrade for 12 months.
Reconstitution :	Reconstitute in PBS or others

Gene Name	CLDN1 claudin 1 [ Homo sapiens ]
Official Symbol	CLDN1
Synonyms	CLDN1; claudin 1; claudin-1; ILVASC; SEMP1; senescence associated epithelial membrane protein 1; senescence-associated epithelial membrane protein 1; CLD1;
Gene ID	9076
mRNA Refseq	NM_021101
Protein Refseq	NP_066924
MIM	603718
UniProt ID	O95832